Proteinuria: Difference between revisions
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imported>Robert Badgett |
imported>Robert Badgett |
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==Diagnosis== | ==Diagnosis== | ||
The standard dipstick test only measures albumin. | |||
The sulfosalicylic acid (SSA) test measure all protein. | |||
===Spot protein/creatinine ratio=== | ===Spot protein/creatinine ratio=== | ||
One study found that in the presence of stable renal function, a protein/creatinine ratio:<ref name="pmid6656849">{{cite journal| author=Ginsberg JM, Chang BS, Matarese RA, Garella S| title=Use of single voided urine samples to estimate quantitative proteinuria. | journal=N Engl J Med | year= 1983 | volume= 309 | issue= 25 | pages= 1543-6 | pmid=6656849 | One study found that in the presence of stable renal function, a protein/creatinine ratio:<ref name="pmid6656849">{{cite journal| author=Ginsberg JM, Chang BS, Matarese RA, Garella S| title=Use of single voided urine samples to estimate quantitative proteinuria. | journal=N Engl J Med | year= 1983 | volume= 309 | issue= 25 | pages= 1543-6 | pmid=6656849 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=6656849 }} | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=6656849 }}</ref> | ||
* > 3.5 (mg/mg) suggests [[nephrotic syndrome]] | * > 3.5 (mg/mg) suggests [[nephrotic syndrome]] | ||
* < 0.2 is within normal limits | * < 0.2 is within normal limits | ||
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===Spot urine albumin/creatinine ratio=== | ===Spot urine albumin/creatinine ratio=== | ||
In adults, albuminuria is a more [[sensitivity and specificity|sensitive]] than total protein in detecting [[chronic kidney disease]] from many glomerular diseases.<ref name="pmid11904577">{{cite journal| author=National Kidney Foundation| title=K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. | journal=Am J Kidney Dis | year= 2002 | volume= 39 | issue= 2 Suppl 1 | pages= S1-266 | pmid=11904577 | In adults, albuminuria is a more [[sensitivity and specificity|sensitive]] than total protein in detecting [[chronic kidney disease]] from many glomerular diseases.<ref name="pmid11904577">{{cite journal| author=National Kidney Foundation| title=K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. | journal=Am J Kidney Dis | year= 2002 | volume= 39 | issue= 2 Suppl 1 | pages= S1-266 | pmid=11904577 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=11904577 }} | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=11904577 }}</ref> | ||
* <30 mg/g is a normal albumin-creatinine ratio | * <30 mg/g is a normal albumin-creatinine ratio | ||
* 30-300 mg/g is microalbuminuria | * 30-300 mg/g is microalbuminuria | ||
Revision as of 09:46, 4 January 2011
In medicine, proteinuria is "the presence of proteins in the urine, an indicator of kidney diseases."[1]
Diagnosis
The standard dipstick test only measures albumin.
The sulfosalicylic acid (SSA) test measure all protein.
Spot protein/creatinine ratio
One study found that in the presence of stable renal function, a protein/creatinine ratio:[2]
- > 3.5 (mg/mg) suggests nephrotic syndrome
- < 0.2 is within normal limits
Spot urine albumin/creatinine ratio
In adults, albuminuria is a more sensitive than total protein in detecting chronic kidney disease from many glomerular diseases.[3]
- <30 mg/g is a normal albumin-creatinine ratio
- 30-300 mg/g is microalbuminuria
References
- ↑ Anonymous (2024), Proteinuria (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Ginsberg JM, Chang BS, Matarese RA, Garella S (1983). "Use of single voided urine samples to estimate quantitative proteinuria.". N Engl J Med 309 (25): 1543-6. PMID 6656849.
- ↑ National Kidney Foundation (2002). "K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.". Am J Kidney Dis 39 (2 Suppl 1): S1-266. PMID 11904577.