Drugs banned from the Olympics

From Citizendium
Revision as of 14:51, 4 June 2008 by imported>David E. Volk (→‎Metabolites and isomers)
Jump to navigation Jump to search
This article has a Citable Version.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article has an approved citable version (see its Citable Version subpage). While we have done conscientious work, we cannot guarantee that this Main Article, or its citable version, is wholly free of mistakes. By helping to improve this editable Main Article, you will help the process of generating a new, improved citable version.

The International Olympic Committee was established in order to deal with the increasing problem of doping in the sports world and follows three fundamental principals, protecting the health of athletes, respecting medical and sports ethics, and ensuring equality for all athletes. The list of drugs banned from the Olympics[1] is determined by the World Anti-Doping Agency. The banned substances and techniques fall into the following categories: androgenic agents, blood doping, peptide hormones, stimulants, diuretics, narcotics and cannabinoids.

Banned androgenic agents

Banned androgenic agents are either anabolic steroids or Beta-2 agonists. Androgenic steroids increase testosterone and epitestosterone, improving muscle strength and endurance. Andro, DHEA, stanozolol, testosterone and nandrolone, or derivates (see below) are banned drugs in this category. Other banned androgenic agents include bambuterol, clenbuterol, salbutamol, tibolone, zeranol, zilpaterol and selective androgen receptor modulators.

Exogenous anabolic androgenic steroids

This is the complete list of exogenous (non-natural) androgenic agents banned as of January 1, 2008:

Drugs with similar structures and biological activity are also banned because new designer drugs of this sort are always being developed in order to beat the drug tests.

Endogenous anabolic androgenic steroids

Metabolites and isomers

  • 5-androstane-3,17-diol
  • 5-androstane-3,17-diol
  • 5-androstane-3,17-diol
  • 5-androstane-3,17-diol
  • androst-4-ene-3,17-diol
  • androst-4-ene-3,17-diol
  • androst-4-ene-3,17-diol
  • androst-4-ene-3,17-diol
  • androst-5-ene-3,17-diol


Blood doping is the injection of red blood cells, related blood products that contain red blood cells, or artificial oxgyen containers. This is done by storing blood prior to competition and injecting immediately before competition to improve oxygen transport and athletic endurance.

Hormones and related substances

Peptide hormones increase bulk, stength, and oxygen-carrying red blood cells. The peptide hormones erythropoietin (EPO), growth hormone (hGH), Insulin-like growth factors (IGF-1, etc.), Mechano growth factors (MGFs), chorionic gonadatrophin (banned in men only), somatotrophin (growth hormone), insulins and corticotrophins, corticosteroid mimics, and their releasing factor, are banned.


Beta-2 agonists

All beta-2 agonists and their D- and L- isomers, are banned. However, formoterol, salbutamol, slmeterol and terbualine may be used with a "therapeutic use exemption", only in the inhaled form.

Hormone antagonists and modulators

All aromatase inhibitors, including but not limited to, anastrozole, letrozole, aminoglutethimide, exemestane, formestane and testolactone are banned. Selective estrogen receptor modulators, including but not limited to raloxifene, tamoxifen and toremifene are banned. Clomiphene, cyclofenil, fulvestrant and all other anti-estrogenic substances are banned. Myostatin inhibitors are banned.

Stimulants

Stimulants directly affect the central nervous system, increasing blood flow and heart rate. Stimulants that are banned include amphetamines, beta-2 agonists, ephedrine, pseudoephedrine, fencamfamine, cocaine, methamphetamines, mesocarb and other substances with similar chemical structures and biological effects, including, but not limited to, the following.

Diuretics and masking agents

Diuretics (and masking agents) are banned for two reasons. First, by decreasing water retention and thus weight, an important consideration in many speed sports, they increase the speed of athletes. Secondly, increase urine production depletes the presence of other drug metabolites, making their detection more difficult.

Diuretics

The following diuretics, and chemicals with similar structure or biological activity are banned.

Narcotics and cannabinoids

Narcotic analgesics decrease the sensation of serious injuries, allowing athletes to continue training or competition after serious injuries. While some pain killers are allowed, including codeine, the following are banned:

The cannabinoids marijuana and hashish are also banned.

Glucocorticoids

The administration of any glucorticoid orally, rectally, intraveniously or intramuscularly is prohibited and requires a therapeutic use exemption. Topical uses of glucocorticoids does not require an exemption.

Beta blockers

Beta blockers are prohibited only during competition, in selected sports. The prohibited beta blockers include, but are not limited to:

References and notes