Cyclic AMP: Difference between revisions
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In [[biochemistry]], '''cyclic AMP''' is an "adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a [[Second messenger system|second messenger]] and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including [[epinephrine]], [[glucagon]], and [[ACTH]]."<ref>{{MeSH}}</ref> | In [[biochemistry]], '''cyclic AMP''' is an "adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a [[Second messenger system|second messenger]] and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including [[epinephrine]], [[glucagon]], and [[ACTH]]."<ref>{{MeSH}}</ref> | ||
In [[signal transduction]], [[cell surface receptor]]s may activate [[second messenger system]]s such as adenyl cyclase-[[cyclic AMP]] and [[cyclic GMP]] which then may activate [[protein kinase]]s which then affect downstream targets (see [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=receptor,kinase,G-protein-coupled&rid=mcb.figgrp.5742 figure]).<ref name="isbn0-7167-3136-3">{{cite book |author=Lodish, Harvey F. |authorlink= |editor= |others= |title=Molecular cell biology |edition= |language= |publisher=Scientific American Books |location=New York |year=1999 |origyear= |chapter=20.1. Overview of Extracellular Signaling|chapterurl=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.section.5717|pages= |quote= |isbn=0-7167-3136-3 |oclc= |doi= |url=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb |accessdate=}}</ref> | |||
==Metabolism== | |||
Cyclic AMP, along with pyrophasphate, are formed by action of the enzyme [[adenylate cyclase]] on [[adenosine triphosphate]] (ATP). | |||
==Pharmacology== | |||
The [[medication]] [[adenosine]] inhibits the effects intracellular cyclic AMP thus reducing [[sympathetic nervous system|sympathetic]] stimulation.<ref name="isbn0-07-142280-3">{{cite book |author=Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred |authorlink= |editor= |others= |title=Goodman & Gilman's the pharmacological basis of therapeutics |edition=11th |language=|chapter=Chapter 34. Antiarrhythmic Drugs |publisher=McGraw-Hill |location=New York |year=2006 |origyear= |pages= |quote= |isbn=0-07-142280-3 |oclc= |doi= |url= |accessdate=}}</ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 10:53, 9 July 2009
In biochemistry, cyclic AMP is an "adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH."[1]
In signal transduction, cell surface receptors may activate second messenger systems such as adenyl cyclase-cyclic AMP and cyclic GMP which then may activate protein kinases which then affect downstream targets (see figure).[2]
Metabolism
Cyclic AMP, along with pyrophasphate, are formed by action of the enzyme adenylate cyclase on adenosine triphosphate (ATP).
Pharmacology
The medication adenosine inhibits the effects intracellular cyclic AMP thus reducing sympathetic stimulation.[3]
References
- ↑ Anonymous (2024), Cyclic AMP (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Lodish, Harvey F. (1999). “20.1. Overview of Extracellular Signaling”, Molecular cell biology. New York: Scientific American Books. ISBN 0-7167-3136-3.
- ↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). “Chapter 34. Antiarrhythmic Drugs”, Goodman & Gilman's the pharmacological basis of therapeutics, 11th. New York: McGraw-Hill. ISBN 0-07-142280-3.