Coagulation: Difference between revisions
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====Warfarin therapy==== | ====Warfarin therapy==== | ||
[[Warfarin]] therapy reduces the [[vitamin K]] dependent cofactors II, VII, IX, and X and the [[vitamin K]] dependent [[Protein C]]. The level of factor II is thought to most influence coagulation..<ref name="pmid9005747">{{cite journal |author=Harrison L, Johnston M, Massicotte MP, Crowther M, Moffat K, Hirsh J |title=Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy |journal=Ann. Intern. Med. |volume=126 |issue=2 |pages=133–6 |year=1997 |pmid=9005747 |doi= |issn=|url=http://www.annals.org/cgi/content/full/126/2/133}}</ref> The levels of factor VII and [[Protein C]] fall the fastest after warfarin is started.<ref name="pmid9005747"/> With the exception of Factor IX, these factors are from either the extrinsic pathway or the final common pathway. | [[Warfarin]] therapy reduces the [[vitamin K]] dependent cofactors II, VII, IX, and X and the [[vitamin K]] dependent [[Protein C]]. The level of factor II is thought to most influence coagulation.<ref name="pmid15522981">{{cite journal |author=Eckhoff CD, Didomenico RJ, Shapiro NL |title=Initiating warfarin therapy: 5 mg versus 10 mg |journal=Ann Pharmacother |volume=38 |issue=12 |pages=2115–21 |year=2004 |pmid=15522981 |doi=10.1345/aph.1E083}}</ref><ref name="pmid9005747">{{cite journal |author=Harrison L, Johnston M, Massicotte MP, Crowther M, Moffat K, Hirsh J |title=Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy |journal=Ann. Intern. Med. |volume=126 |issue=2 |pages=133–6 |year=1997 |pmid=9005747 |doi= |issn=|url=http://www.annals.org/cgi/content/full/126/2/133}}</ref> The levels of factor VII and [[Protein C]] fall the fastest after warfarin is started.<ref name="pmid9005747"/> With the exception of Factor IX, these factors are from either the extrinsic pathway or the final common pathway. | ||
The effect of warfarin is measured by the [[prothrombin time]] (or the [[International Normalized Ratio]] derived from the prothrombin time) although warfarin can also affect the partial thromboplastin time.<ref name="pmid3397749">{{cite journal |author=Bell DF, Harris WH, Kuter DJ, Wessinger SJ |title=Elevated partial thromboplastin time as an indicator of hemorrhagic risk in postoperative patients on warfarin prophylaxis |journal=J Arthroplasty |volume=3 |issue=2 |pages=181–4 |year=1988 |pmid=3397749 |doi=}}</ref><ref name="pmid3816546">{{cite journal |author=Hauser VM, Rozek SL |title=Effect of warfarin on the activated partial thromboplastin time |journal=Drug Intell Clin Pharm |volume=20 |issue=12 |pages=964–7 |year=1986 |pmid=3816546 |doi=}}</ref> | The effect of warfarin is measured by the [[prothrombin time]] (or the [[International Normalized Ratio]] derived from the prothrombin time) although warfarin can also affect the partial thromboplastin time.<ref name="pmid3397749">{{cite journal |author=Bell DF, Harris WH, Kuter DJ, Wessinger SJ |title=Elevated partial thromboplastin time as an indicator of hemorrhagic risk in postoperative patients on warfarin prophylaxis |journal=J Arthroplasty |volume=3 |issue=2 |pages=181–4 |year=1988 |pmid=3397749 |doi=}}</ref><ref name="pmid3816546">{{cite journal |author=Hauser VM, Rozek SL |title=Effect of warfarin on the activated partial thromboplastin time |journal=Drug Intell Clin Pharm |volume=20 |issue=12 |pages=964–7 |year=1986 |pmid=3816546 |doi=}}</ref> | ||
Revision as of 04:46, 25 January 2008
Coagulation is "the process of the interaction of blood coagulation factors that results in an insoluble fibrin clot."[1]
Biochemistry
| Cofactor | Pathway | Half-life[2] |
|---|---|---|
| Factor II (prothrombin) | Final common | 3 days |
| Factor VII | Intrinsic pathway | 5-7 hours |
| Factor IX | Intrinsic pathway | 24 hours |
| Factor X | Extrinsic pathway | 40 hours |
All coagulation factors are produced in the liver except for von Willebrand's factor which is made in blood vessels and the spleen.[3] The synthesis of coagulation factors II, VII, IX, and X and proteins C and S is dependent on vitamin K.[4] The half-lives of the cofactors range from five to seven hours for factor VII to 3 days for factor II (prothrombin).
Details and figures depicting the coagulation pathways are available online at the National Library of Medicine.[5]
Intrinsic pathway
The intrinsic pathway uses Factors VIII, IX, XI, and XII. The partial thromboplastin time measures the function of the intrinsic pathway and the common pathway.
Extrinsic pathway
The extrinsic pathway uses Factors VII and X. The prothrombin time measures the function of the extrinsic pathway and the common pathway.
Final common pathway
The final common pathway used factors II (prothrombin) and I (fibrinogen).
Disorders of coagulation
Blood coagulation disorders are "hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as coagulation protein disorders; blood platelet disorders; blood protein disorders or nutritional conditions."[6]
Factor I deficiency
Deficiency of Factor I (fibrinogen) may be inherited (afibrinogenemia) or acquired.
Factor II deficiency
Deficiency of Factor II (prothrombin) leads to hypoprothrombinemia. The defiency may be acquired in due to prothrombin antibodies.[7]
Factor V deficiency
Factor V deficiency is a "(known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren's disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait."[8]
Factor X deficiency
Factor X deficiency is a "blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption."[9]
Multiple factor deficiencies
Heparin therapy
Heparin therapy primarily affects Factors IX and X of the intrinsic pathway.
The effect of heparin is monitored by the partial thromboplastin time. However, it can affect the prothrombin time as well.[10] and extend the prothrombin time by one to two seconds.[11]
Warfarin therapy
Warfarin therapy reduces the vitamin K dependent cofactors II, VII, IX, and X and the vitamin K dependent Protein C. The level of factor II is thought to most influence coagulation.[2][12] The levels of factor VII and Protein C fall the fastest after warfarin is started.[12] With the exception of Factor IX, these factors are from either the extrinsic pathway or the final common pathway.
The effect of warfarin is measured by the prothrombin time (or the International Normalized Ratio derived from the prothrombin time) although warfarin can also affect the partial thromboplastin time.[13][14]
Cirrhosis
Cirrhosis affects all coagulation factors except von Willebrand's factor and Factor VIII.[3][4]
Disseminated intravascular coagulation
Disseminated intravascular coagulation (DIC) affects all coagulation factors.
References
- ↑ Anonymous. Blood coagulation. National Library of Medicine. Retrieved on 2008-01-10.
- ↑ 2.0 2.1 Eckhoff CD, Didomenico RJ, Shapiro NL (2004). "Initiating warfarin therapy: 5 mg versus 10 mg". Ann Pharmacother 38 (12): 2115–21. DOI:10.1345/aph.1E083. PMID 15522981. Research Blogging.
- ↑ 3.0 3.1 Sallah S, Bobzien W (1999). "Bleeding problems in patients with liver disease. Ways to manage the many hepatic effects on coagulation". Postgrad Med 106 (4): 187–90, 193–5. PMID 10533518. [e]
- ↑ 4.0 4.1 Mammen EF (1992). "Coagulation abnormalities in liver disease". Hematol. Oncol. Clin. North Am. 6 (6): 1247–57. PMID 1333467. [e]
- ↑ Tymoczko, John L.; Stryer Berg Tymoczko; Stryer, Lubert; Berg, Jeremy Mark (2002). Biochemistry. New York: W.H. Freeman and Company. ISBN 0-7167-4955-6. Figure of coagulation pathways
- ↑ Anonymous. Blood Coagulation Disorders. National Library of Medicine.
- ↑ Bajaj SP, Rapaport SI, Fierer DS, Herbst KD, Schwartz DB (1983). "A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome". Blood 61 (4): 684–92. PMID 6403077. [e]
- ↑ Anonymous. Factor V Deficiency. National Library of Medicine.
- ↑ Anonymous. Factor X Deficiency. National Library of Medicine.
- ↑ Schultz NJ, Slaker RA, Rosborough TK (1991). "The influence of heparin on the prothrombin time". Pharmacotherapy 11 (4): 312–6. PMID 1923913. [e]
- ↑ Lutomski DM, Djuric PE, Draeger RW (1987). "Warfarin therapy. The effect of heparin on prothrombin times". Arch. Intern. Med. 147 (3): 432–3. PMID 3827418. [e]
- ↑ 12.0 12.1 Harrison L, Johnston M, Massicotte MP, Crowther M, Moffat K, Hirsh J (1997). "Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy". Ann. Intern. Med. 126 (2): 133–6. PMID 9005747. [e]
- ↑ Bell DF, Harris WH, Kuter DJ, Wessinger SJ (1988). "Elevated partial thromboplastin time as an indicator of hemorrhagic risk in postoperative patients on warfarin prophylaxis". J Arthroplasty 3 (2): 181–4. PMID 3397749. [e]
- ↑ Hauser VM, Rozek SL (1986). "Effect of warfarin on the activated partial thromboplastin time". Drug Intell Clin Pharm 20 (12): 964–7. PMID 3816546. [e]