Apolipoprotein: Difference between revisions
imported>Robert Badgett (New page: In medicine and biochemistry, '''apolipoproteins''' are "protein components on the surface of lipoproteins. They form a layer surrounding the hydrophobic lipid core. There ...) |
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===Hypoalphalipoproteinemia=== | ===Hypoalphalipoproteinemia=== | ||
{{main|Hypoalphalipoproteinemia}} | {{main|Hypoalphalipoproteinemia}} | ||
Mutations in the gene encoding [[apolipoprotein A-I]] is one cause of the familial [[dyslipidemia]] [[hypoalphalipoproteinemia]]. | Mutations in the gene encoding [[apolipoprotein A-I]] is one cause of the familial [[dyslipidemia]] [[hypoalphalipoproteinemia]]. | ||
===Hyperlipoproteinemia Type I=== | ===Hyperlipoproteinemia Type I=== | ||
Mutations in the gene encoding [[apolipoprotein C-II]] is one cause of the familial [[dyslipidemia]] [[hyperlipoproteinemia Type I]]. | Mutations in the gene encoding [[apolipoprotein C-II]] is one cause of the familial [[dyslipidemia]] [[hyperlipoproteinemia Type I]]. | ||
===Hyperlipoproteinemia Type III=== | ===Hyperlipoproteinemia Type III=== | ||
Mutations in the gene encoding [[apolipoprotein E]] is the cause of the familial [[dyslipidemia]] [[hyperlipoproteinemia Type III]]. | Mutations in the gene encoding [[apolipoprotein E]] is the cause of the familial [[dyslipidemia]] [[hyperlipoproteinemia Type III]]. | ||
Revision as of 05:22, 18 November 2009
In medicine and biochemistry, apolipoproteins are "protein components on the surface of lipoproteins. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and lipid metabolism. These proteins are synthesized mainly in the liver and the intestines."[1]
Classification
- Apolipoprotein A (apo A) is the structural protein of high density lipoproteins (alpha-lipoproteins).
- Apolipoprotein A-I (apo AI)
- Apolipoprotein A-II
- Apolipoproteins B
- Apolipoprotein B-100 (apo B-100) is the structural protein of LDL lipoproteins and VLDL lipoproteins.
- Apolipoprotein B-48 (apo B-48) is the structural protein of chylomicrons.
- Apolipoproteins C
- Apolipoprotein C-I
- Apolipoprotein C-II.
- Apolipoprotein C-III
- Apolipoproteins D
- Apolipoproteins E.
- Apolipoprotein E2
- Apolipoprotein E3
- Apolipoprotein E4
Role in dyslipidemias
Hypoalphalipoproteinemia
Mutations in the gene encoding apolipoprotein A-I is one cause of the familial dyslipidemia hypoalphalipoproteinemia.
Hyperlipoproteinemia Type I
Mutations in the gene encoding apolipoprotein C-II is one cause of the familial dyslipidemia hyperlipoproteinemia Type I.
Hyperlipoproteinemia Type III
Mutations in the gene encoding apolipoprotein E is the cause of the familial dyslipidemia hyperlipoproteinemia Type III.
Role as a diagnostic tests
Measurement of serum apolipoproteins are an alternative to measuring cholesterol levels in determining risk of vascular disease from atherosclerosis.[2]
References
- ↑ Anonymous (2024), Apolipoprotein (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Emerging Risk Factors Collaboration. Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK et al. (2009). "Major lipids, apolipoproteins, and risk of vascular disease.". JAMA 302 (18): 1993-2000. DOI:10.1001/jama.2009.1619. PMID 19903920. Research Blogging.