Antiemetic agent: Difference between revisions
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In [[medicine]], '''antiemetic agents''' are [[medication]]s to "prevent [[nausea]] or [[vomit]]ing. Antiemetics act by a wide range of mechanisms. Some act on the medullary control centers (the vomiting center and the chemoreceptive trigger zone) while others affect the peripheral receptors."<ref>{{MeSH}}</ref> | In [[medicine]], '''antiemetic agents''' are [[medication]]s to "prevent [[nausea]] or [[vomit]]ing. Antiemetics act by a wide range of mechanisms. Some act on the medullary control centers (the vomiting center and the chemoreceptive trigger zone) while others affect the peripheral receptors."<ref>{{MeSH}}</ref> | ||
In a [[randomized controlled trial]] that compared [[droperidol]], [[metoclopramide]], and [[prochlorperazine]], droperidol was more effective but also caused more self-reported [[ | In a [[randomized controlled trial]] that compared [[droperidol]], [[metoclopramide]], and [[prochlorperazine]], droperidol was more effective but also caused more self-reported [[psychomotor agitation]].<ref name="pmid16490647">Braude D et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID 16490647</ref> | ||
In a [[randomized controlled trial]] [[ondansetron]] and [[droperidol]] were similar.<ref name="pmid15190136">{{cite journal| author=Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I et al.| title=A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. | journal=N Engl J Med | year= 2004 | volume= 350 | issue= 24 | pages= 2441-51 | pmid=15190136 | doi=10.1056/NEJMoa032196 | pmc=PMC1307533 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15190136 }} </ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 09:20, 6 August 2012
In medicine, antiemetic agents are medications to "prevent nausea or vomiting. Antiemetics act by a wide range of mechanisms. Some act on the medullary control centers (the vomiting center and the chemoreceptive trigger zone) while others affect the peripheral receptors."[1]
In a randomized controlled trial that compared droperidol, metoclopramide, and prochlorperazine, droperidol was more effective but also caused more self-reported psychomotor agitation.[2]
In a randomized controlled trial ondansetron and droperidol were similar.[3]
References
- ↑ Anonymous (2024), Antiemetic agent (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Braude D et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID 16490647
- ↑ Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I et al. (2004). "A factorial trial of six interventions for the prevention of postoperative nausea and vomiting.". N Engl J Med 350 (24): 2441-51. DOI:10.1056/NEJMoa032196. PMID 15190136. PMC PMC1307533. Research Blogging.