Antiemetic agent

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In medicine, antiemetic agents are medications to "prevent nausea or vomiting. Antiemetics act by a wide range of mechanisms. Some act on the medullary control centers (the vomiting center and the chemoreceptive trigger zone) while others affect the peripheral receptors."[1]

In a randomized controlled trial that compared droperidol, metoclopramide, and prochlorperazine, droperidol was more effective but also caused more self-reported psychomotor agitation.[2]

In a randomized controlled trial ondansetron and droperidol were similar.[3]


  1. Anonymous (2023), Antiemetic agent (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Braude D et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID 16490647
  3. Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I et al. (2004). "A factorial trial of six interventions for the prevention of postoperative nausea and vomiting.". N Engl J Med 350 (24): 2441-51. DOI:10.1056/NEJMoa032196. PMID 15190136. PMC PMC1307533. Research Blogging.