Anti-nuclear antibodies: Difference between revisions
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In [[medicine]], '''anti-nuclear antibodies''' are "[[autoantibody|autoantibodies]] directed against various nuclear antigens including [[DNA]], [[RNA]], [[histone]]s, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including [[systemic lupus erythematosus]], [[Sjogren's syndrome]], [[scleroderma]], [[polymyositis]], and [[mixed connective tissue disease]].<ref>{{MeSH}}</ref> | In [[medicine]], '''anti-nuclear antibodies''' are "[[autoantibody|autoantibodies]] directed against various nuclear antigens including [[DNA]], [[RNA]], [[histone]]s, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including [[systemic lupus erythematosus]], [[Sjogren's syndrome]], [[scleroderma]], [[polymyositis]], and [[mixed connective tissue disease]].<ref>{{MeSH}}</ref> | ||
They include: | A first and indirect measurement of these antibodies was the 1940-vintage lupus cell preparation, a microscopic procedure no longer used. They include:<ref>{{citation | ||
| contribution = Chapter 5: Laboratory tests in rheumatic disorders | |||
| author = Peter H. Schur and Rober H. Scherling | |||
| title = Practical Rheumatology | |||
| edition = Third | |||
| publisher = Mosby | |||
| year = 2004 | |||
| isbn = 03230299396}}</ref> | |||
*[[Antineutrophil cytoplasmic antibodies]] (ANCA) | *[[Antineutrophil cytoplasmic antibodies]] (ANCA) | ||
*[[Anti-single-stranded DNA]] (ssDNA) | |||
*[[Anti-double-stranded DNA]] (dsDNA) | |||
*[[Anti-Smith antibodies|Anti-Smith]] (anti-Sm) and [[anti-ribonucleoprotein antibodies]] (anti-RNP) | |||
*[[Antiphospholipid antibodies]] | *[[Antiphospholipid antibodies]] | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 21:14, 29 July 2010
In medicine, anti-nuclear antibodies are "autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.[1]
A first and indirect measurement of these antibodies was the 1940-vintage lupus cell preparation, a microscopic procedure no longer used. They include:[2]
- Antineutrophil cytoplasmic antibodies (ANCA)
- Anti-single-stranded DNA (ssDNA)
- Anti-double-stranded DNA (dsDNA)
- Anti-Smith (anti-Sm) and anti-ribonucleoprotein antibodies (anti-RNP)
- Antiphospholipid antibodies
References
- ↑ Anonymous (2024), Anti-nuclear antibodies (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Peter H. Schur and Rober H. Scherling (2004), Chapter 5: Laboratory tests in rheumatic disorders, Practical Rheumatology (Third ed.), Mosby, ISBN 03230299396