Valacyclovir

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In pharmacology and virology, valacyclovir (Valtrex) is "a prodrug of acyclovir; 53% of oral dose excreted as acyclovir in the urine; a 200-400% improvement on acyclovir; used in the management of HSV and VZV infections and the prophylaxis of HCMV infections; RN given refers to the monohydrochloride L-valine isomer."[1]

History

Valtrex brand of valacyclovir was approved by the Food and Drug Administration in the United States with a New Drug Application (NDA) in 1995.[2] A generic version with a AB Therapeutic Equivalence Code was approved with a Abbreviated New Drug Application (ANDA) in 2007.[3]

Usage

Valacyclovir suppressive therapy can reduce the frequency of recurrence of herpes labialis from herpes simplex virus; however, this usage is not approved by the United States Food and Drug Administration.[4][5][6]

Valacyclovir suppressive therapy can reduce the frequency of recurrence of herpes genitalis from herpes simplex virus and this usage is approved by the United States Food and Drug Administration.[6]

External links

The most up-to-date information about Valacyclovir and other drugs can be found at the following sites.


References