Cefonicid

(CC) Image: David E. Volk
cefonicid
IUPAC name: see chemistry section Synonyms: Formula: C18H18N6O8S3
Uses:	antibiotic drug
Properties:	beta-lactam
Hazards:	see drug interactions
Mass (g/mol): CAS #: 542.5660 61270-58-4

Cefonicid, also known as cefonicido and cefonicidum, is a second-generation cephalosporin type of antibiotic medication. It antibacterial activity is due to the core beta-lactam structure which interacts with penicillin-binding proteins within bacteria, thus distruption bacterial cell wall synthesis. It is sold under the brand names Monocid and Praticef. It is administered intravenously or intramuscularly for treatment of urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

Chemistry

The IUPAC name of cefonicid is (6R,7R)-7-[(2-hydroxy-2-phenylacetyl)amino]-8-oxo-3-[[1-(sulfomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Its chemical formula, C₁₈H₁₈N₆O₈S₃, gives it a molecule mass of 542.5660 grams/mole. Like penicillins and other cephalosporins, cefonicid's antibacterial activity is due to the presence of a beta-lactam, which can react with penicillin-binding proteins through an acylation reaction.

References

The most up-to-date information about Cefonicid and other drugs can be found at the following sites.

• Cefonicid - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Cefonicid - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
• Cefonicid - Detailed information from DrugBank.