Purinoceptor P2Y12

In biochemistry and signal transduction, purinoceptor P2Y₁₂ is a G-protein-coupled receptor (a cell surface receptor). It is a subtype of purinergic P2 receptor that is a "receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system; not activated by UDP and UTP; involved in platelets aggregation; a potential target for the treatment of thromboembolisms and other clotting disorders."

Clinical role

Blockers of P2Y₁₂ include the thienopyridines clopidogrel and prasugrel which are irreversible and require at least 1 hour or longer to inhibit platelets. Cangrelor is a reversible blocker that acts quicker.