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...ted to monogenic causes. Many of these are mutations of proteins in the “[[leptin]] pathway” which has an important role in energy balance. Each of those r {{Image|Leptin_pathway2.png|centre|550px|Leptin pathway}}

...n the regulation of appetite. They are directly activated in response to [[leptin]], a hormone releasec from [[adipocyte]]s that circulates in concentrations

...besity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insul ==Leptin==

...taneous fat explains the association between insulin resistance and plasma leptin concentrations. ''Diabetes'' 51:1005-15</ref> ...ly caused by a deficiency in leptin; instead there seems to be a defect in leptin signalling. Adipocytes also produce an array of other peptides including [[

...appetite. There seems to be a correlation between AMPK and the hormones [[leptin]] and [[ghrelin]] which have opposite effects on energy uptake. While it is ...o observe the effects of AMPK in the hypothalamus. AMPK was decreased when leptin was injected, while ghrelin caused an increase in production. The effects w

...many peptide hormones secreted by peripheral endocrine tissues, such as [[leptin]], [[ghrelin]], [[angiotensin]] and [[insulin]]. Also pituitary hormones, [ ...creted from the [[stomach]]. These have important effects on [[appetite]]; leptin normally acts to suppress appetite, whereas ghrelin, which is secreted from

*Increase in hormones such as leptin and insulin with weight gain ...o the extent that leptin may increase blood pressure, then the increase in leptin with subcutaneous fat cells (particularly when they become enlarged) could

...that is a potent stimulator of hunger. Conversely, they are inhibited by [[leptin]], a hormone secreted by [[adipocyte]]s in proportion to total body fat mas

...energy intake is used – i.e. how fat we get<ref>Ahima RS ''et al.'' (2000) Leptin regulation of neuroendocrine systems ''Front Neuroendocrinol'' 21:263-307 < Recently, several new hormonal systems have been discovered - [[leptin]] released by [[adipocytes]] (fat cells) and [[ghrelin]] released from the

...aisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. ''Nature''. 1998 Ma

...f GABA and NPY was confirmed at these nerve terminals.<ref name=Cowley14/> Leptin also acts at the GABA nerve terminals to reduce the inhibition of POMC neur

<ref name="pmid15356017">{{cite journal| author=Ahima R, Osei SY| title=Leptin and appetite control in lipodystrophy. | journal=J Clin Endocrinol Metab |

''Studies the effects leptin, ghrelin and pharmacological substances have on AMPK, believed to be part o

...74:579-84</ref> Among other inputs, the reduced plasma concentrations of [[leptin]] and [[insulin]] that accompany a reduced fat mass result in an increased ...nutrient availability. Signals from the periphery (including the hormones leptin and [[insulin]]) were not increased by exercise regimes, but acute bouts o

...and restricted restricted offspring ate less and had higher fasting plasma leptin as adults, an adaptation which was accompanied by changes in energy sensing ...mechanisms involved, which include changes in fetal cortisol, insulin, and leptin secretion or sensitivity. Intrauterine growth retardation can be induced by

...to orlistat in relation to leptin, as, when using sibutramine, transfer of leptin into the brain is maintained or even increased during weight loss which doe

...inflammatory [[cytokines]] (such as TNF-α, IL-6, IL-1) and [[adipokines]] (leptin, adiponectin, and resistin) from [[adipocytes]]<ref name=Nar />.

...le cerebral artery occlusion and reperfusion by a mechanism independent of leptin deficiency. Monocyte chemoattractant protein-1 appears to contribute to the

...obese individuals, the [[hypothalamus]] does not respond appropriately to leptin. ...ily history of obesity, the earliest obesogenic changes are not related to leptin, but to metabolic efficiency and to insulin status and responsiveness: subj

{{rpr|Leptin}} (31 Mar)