Fatty liver: Difference between revisions
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In [[medicine]], '''fatty liver''', also called '''hepatic steatosis''' or '''liver steatosis''' is "lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of [[triglyceride]]s, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of [[fatty acid]]s."<ref>{{MeSH}}</ref> | In [[medicine]], '''fatty liver''', also called '''hepatic steatosis''' or '''liver steatosis''' is "lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of [[triglyceride]]s, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of [[fatty acid]]s."<ref>{{MeSH}}</ref> | ||
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Fatty liver and [[steatohepatitis]] may be caused by the [[single-nucleotide polymorphism]]s [http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2854116 rs2854116] (c.455T>C) and [http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2854117 rs2854117] (c.482C>T) of [[apolipoprotein C-III]] which are also associated with [[insulin resistance]] and [[hypertriglyceridemia]].<ref name="pmid20335584">{{cite journal| author=Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM et al.| title=Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. | journal=N Engl J Med | year= 2010 | volume= 362 | issue= 12 | pages= 1082-9 | pmid=20335584 | Fatty liver and [[steatohepatitis]] may be caused by the [[single-nucleotide polymorphism]]s [http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2854116 rs2854116] (c.455T>C) and [http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2854117 rs2854117] (c.482C>T) of [[apolipoprotein C-III]] which are also associated with [[insulin resistance]] and [[hypertriglyceridemia]].<ref name="pmid20335584">{{cite journal| author=Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM et al.| title=Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. | journal=N Engl J Med | year= 2010 | volume= 362 | issue= 12 | pages= 1082-9 | pmid=20335584 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=20335584 | doi=10.1056/NEJMoa0907295 }} </ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=20335584 | doi=10.1056/NEJMoa0907295 }} </ref> | ||
[[Obesity]] may be the cause of cirrhosis in 12% of patients.<ref name="pmid2227807">{{cite journal| author=Wanless IR, Lentz JS| title=Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. | journal=Hepatology | year= 1990 | volume= 12 | issue= 5 | pages= 1106-10 | pmid=2227807 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=2227807 }} </ref><ref name="pmid9005748">{{cite journal| author=Sheth SG, Gordon FD, Chopra S| title=Nonalcoholic steatohepatitis. | journal=Ann Intern Med | year= 1997 | volume= 126 | issue= 2 | pages= 137-45 | pmid=9005748 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=9005748 }} </ref> | |||
==Epidemiology/prevalence== | |||
Fatty liver and [[steatohepatitis]] are common, especially in diabetics and overweight people.<ref name="pmid20858492">{{cite journal| author=Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M et al.| title=Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. | journal=Gastroenterology | year= 2011 | volume= 140 | issue= 1 | pages= 124-31 | pmid=20858492 | doi=10.1053/j.gastro.2010.09.038 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20858492 }} </ref> | |||
==Prognosis== | |||
===NAFLD fibrosis score=== | |||
* http://nafldscore.com/ | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 11:10, 12 May 2015
In medicine, fatty liver, also called hepatic steatosis or liver steatosis is "lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of triglycerides, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of fatty acids."[1]
Fatty liver includes steatohepatitis.
Etiology / cause
Fatty liver and steatohepatitis may be caused by the single-nucleotide polymorphisms rs2854116 (c.455T>C) and rs2854117 (c.482C>T) of apolipoprotein C-III which are also associated with insulin resistance and hypertriglyceridemia.[2]
Obesity may be the cause of cirrhosis in 12% of patients.[3][4]
Epidemiology/prevalence
Fatty liver and steatohepatitis are common, especially in diabetics and overweight people.[5]
Prognosis
NAFLD fibrosis score
References
- ↑ Anonymous (2024), Fatty liver (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM et al. (2010). "Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.". N Engl J Med 362 (12): 1082-9. DOI:10.1056/NEJMoa0907295. PMID 20335584. Research Blogging.
- ↑ Wanless IR, Lentz JS (1990). "Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors.". Hepatology 12 (5): 1106-10. PMID 2227807.
- ↑ Sheth SG, Gordon FD, Chopra S (1997). "Nonalcoholic steatohepatitis.". Ann Intern Med 126 (2): 137-45. PMID 9005748.
- ↑ Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M et al. (2011). "Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.". Gastroenterology 140 (1): 124-31. DOI:10.1053/j.gastro.2010.09.038. PMID 20858492. Research Blogging.