Fatty liver
In medicine, fatty liver, also called hepatic steatosis or liver steatosis is "lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of triglycerides, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of fatty acids."[1]
Fatty liver includes steatohepatitis.
Etiology / cause
Fatty liver and steatohepatitis may be caused by the single-nucleotide polymorphisms rs2854116 (c.455T>C) and rs2854117 (c.482C>T) of apolipoprotein C-III which are also associated with insulin resistance and hypertriglyceridemia.[2]
Obesity may be the cause of cirrhosis in 12% of patients.[3][4]
Epidemiology/prevalence
Fatty liver and steatohepatitis are common, especially in diabetics and overweight people.[5]
Prognosis
NAFLD fibrosis score
References
- ↑ Anonymous (2023), Fatty liver (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM et al. (2010). "Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.". N Engl J Med 362 (12): 1082-9. DOI:10.1056/NEJMoa0907295. PMID 20335584. Research Blogging.
- ↑ Wanless IR, Lentz JS (1990). "Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors.". Hepatology 12 (5): 1106-10. PMID 2227807.
- ↑ Sheth SG, Gordon FD, Chopra S (1997). "Nonalcoholic steatohepatitis.". Ann Intern Med 126 (2): 137-45. PMID 9005748.
- ↑ Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M et al. (2011). "Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.". Gastroenterology 140 (1): 124-31. DOI:10.1053/j.gastro.2010.09.038. PMID 20858492. Research Blogging.