Ribavirin: Difference between revisions

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[[Image:Ribavirin structure.jpg|right|thumb|150px|{{#ifexist:Template:Ribavirin structure.jpg/credit|{{Ribavirin structure.jpg/credit}}<br/>|}}Ribavirin]]
   
'''Ribavirin''' ('''RBV''') is a [[nucleoside]] antimetabolite [[antiviral drug]] that blocks [[nucleic acid]] synthesis that is used to treat both [[RNA]] and [[DNA]] [[viruses]], including [[hepatitis C]] virus (HCV) and [[respiratory syncytial virus]] (RSV).  An oral formulation is used in combination with interferon drugs in the treatment of HCV, but the aerosol form is used to treatet RSV. Its structural similarity with RNA molecules (its contains a ribose derivative) allows it to inhibit the enzyme RNA-dependent RNA polymerase.  The triphosphate form of the drug inhibits [[inosine monophosphate dehydrogenase]] (IMPD), viral RNA polymerase and messenger RNA (mRNA) viral guanylyltransferase.  Incorporation of the drug into the viral genome cause lethal mutations.


Its IUPAC chemical name is 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide and its molecular formula is C<sub>8</sub>H<sub>12</sub>N<sub>4</sub>O<sub>5</sub>.
{{Chem infobox
|align=right
|image=[[Image:Ribavirin structure.jpg|center|thumb|200px]]
|width=200px
|molname=ribavirin
|synonyms=see below
|molformula=C<sub>8</sub>H<sub>12</sub>N<sub>4</sub>O<sub>5</sub>
|molmass=244.2047
|uses=treat RNA or DNA viruses
|properties=nucleic acid competitor
|hazards=see drug interactions
|iupac= see chemistry section
|casnumber=36791-04-5
}}
 
 
'''Ribavirin''' ('''RBV''') is a  [[nucleoside]] antimetabolite [[antiviral drug]] that blocks [[nucleic acid]] synthesis that is used to treat both [[RNA]] and [[DNA]] [[virus]]es, including [[hepatitis C]] virus (HCV) and [[respiratory syncytial virus]] (RSV).  An oral formulation is used in combination with interferon drugs in the treatment of HCV, but the aerosol form is used to treatet RSV. Its structural similarity with RNA molecules (its contains a ribose derivative) allows it to inhibit the enzyme RNA-dependent RNA polymerase.  The triphosphate form of the drug inhibits [[inosine monophosphate dehydrogenase]] (IMPD), viral RNA polymerase and messenger RNA (mRNA) viral guanylyltransferase.  Incorporation of the drug into the viral genome causes lethal mutations.
 
Its IUPAC chemical name is 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide and its molecular formula is C<sub>8</sub>H<sub>12</sub>N<sub>4</sub>O<sub>5</sub>, giving it a molecular mass of 244.2047 g/mol.
 
== Synonyms and brand names ==
''synonyms''
*RBV
*Ribavirin Triphosphate
*Ribavirina
*Ribavirine
*Ribavirinum
''Brand Names''
*Copegus®
*RIBAV®
*RTC®
*RTCA®
*RTP®
*Rebetol®
*Rebetron®
*Rebretron®
*Ribamide®
*Ribamidil®
*Ribamidyl®
*Ribasphere®
*Ribavirin Capsules®
*Ribavirin-TP®
*Tribavirin®
*Varazid®
*Vilona®
*Viramid®
*Virazid®
*Virazole®
*Virazole 5'-triphosphate®


== External links ==
== External links ==
* {{subpages}}
{{CZMed}}
* Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00811.txt

Latest revision as of 01:21, 3 June 2009

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Ribavirin structure.jpg
ribavirin
IUPAC name: see chemistry section
Synonyms: see below
Formula: C8H12N4O5
 Uses: treat RNA or DNA viruses
 Properties: nucleic acid competitor
 Hazards: see drug interactions
Mass (g/mol): CAS #:
244.2047 36791-04-5



Ribavirin (RBV) is a nucleoside antimetabolite antiviral drug that blocks nucleic acid synthesis that is used to treat both RNA and DNA viruses, including hepatitis C virus (HCV) and respiratory syncytial virus (RSV). An oral formulation is used in combination with interferon drugs in the treatment of HCV, but the aerosol form is used to treatet RSV. Its structural similarity with RNA molecules (its contains a ribose derivative) allows it to inhibit the enzyme RNA-dependent RNA polymerase. The triphosphate form of the drug inhibits inosine monophosphate dehydrogenase (IMPD), viral RNA polymerase and messenger RNA (mRNA) viral guanylyltransferase. Incorporation of the drug into the viral genome causes lethal mutations.

Its IUPAC chemical name is 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide and its molecular formula is C8H12N4O5, giving it a molecular mass of 244.2047 g/mol.

Synonyms and brand names

synonyms

  • RBV
  • Ribavirin Triphosphate
  • Ribavirina
  • Ribavirine
  • Ribavirinum

Brand Names

  • Copegus®
  • RIBAV®
  • RTC®
  • RTCA®
  • RTP®
  • Rebetol®
  • Rebetron®
  • Rebretron®
  • Ribamide®
  • Ribamidil®
  • Ribamidyl®
  • Ribasphere®
  • Ribavirin Capsules®
  • Ribavirin-TP®
  • Tribavirin®
  • Varazid®
  • Vilona®
  • Viramid®
  • Virazid®
  • Virazole®
  • Virazole 5'-triphosphate®

External links

The most up-to-date information about Ribavirin and other drugs can be found at the following sites.

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