imported>Richard T Murray |
imported>Derek Harkness |
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| As a dipeptide, aspartame is made of two normal, essential amino acids: phenylalanine (50 % by weight) and aspartic acid, (39 %), loosely bound together by a smaller methyl unit (11 %). At temperatures above body heat and high levels of acidity(low pH) after ingestion, it readily splits and releases its three components, which follow largely independent paths in humans. | | As a dipeptide, aspartame is made of two normal, essential amino acids: phenylalanine (50 % by weight) and aspartic acid, (39 %), loosely bound together by a smaller methyl unit (11 %). At temperatures above body heat and high levels of acidity(low pH) after ingestion, it readily splits and releases its three components, which follow largely independent paths in humans. |
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| formaldehyde, aspartame, and migraines, the first case series, Sharon E Jacob-Soo, Sarah A Stechschulte, UCSD, Dermatitis 2008 May: Rich Murray 2008.07.18
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| http://rmforall.blogspot.com/2008_07_01_archive.htm
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| Friday, July 18, 2008
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| http://groups.yahoo.com/group/aspartameNM/message/1553
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| Dermatitis. 2008 May-Jun; 19(3): E10-1.
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| Formaldehyde, aspartame, and migraines: a possible connection.
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| Jacob SE, Stechschulte S.
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| Department of Dermatology and Cutaneous Surgery, University of Miami,
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| Miami, FL, USA.
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|
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| Aspartame is a widely used artificial sweetener that has been linked
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| to pediatric and adolescent migraines.
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| Upon ingestion, aspartame is broken, converted, and oxidized into
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| formaldehyde in various tissues.
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| We present the first case series of aspartame-associated migraines
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| related to clinically relevant positive reactions to formaldehyde on
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| patch testing. PMID: 18627677
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| formaldehyde from many sources, including aspartame, is major cause of
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| Allergic Contact Dermatitis, SE Jacob, T Steele, G Rodriguez, Skin and
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| Aging 2005 Dec.: Murray 2008.03.27
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| http://rmforall.blogspot.com/2008_03_01_archive.htm
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| Thursday, March 27, 2008
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| http://groups.yahoo.com/group/aspartameNM/message/1533
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|
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| "For example, diet soda and yogurt containing aspartame (Nutrasweet),
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| release formaldehyde in their natural biological degradation.
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| One of aspartame's metabolites, aspartic acid methyl ester, is
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| converted to methanol in the body, which is oxidized to formaldehyde
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| in all organs, including the liver and eyes. 22
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| Patients with a contact dermatitis to formaldehyde have been seen to
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| improve once aspartame is avoided. 22
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| Notably, the case that Hill and Belsito reported had a 6-month history
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| of eyelid dermatitis that subsided after 1 week of avoiding diet soda.
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| 22"
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| Avoiding formaldehyde allergic reactions in children, aspartame,
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| vitamins, shampoo, conditioners, hair gel, baby wipes, Sharon E Jacob,
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| MD, Tace Steele, U. Miami, Pediatric Annals 2007 Jan.: eyelid contact
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| dermatitis, AM Hill, DV Belsito, 2003 Nov.: Murray 2008.03.27
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| http://rmforall.blogspot.com/2008_03_01_archive.htm
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| Thursday, March 27, 2008
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| http://groups.yahoo.com/group/aspartameNM/message/1532
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| Sharon E. Jacob, MD, Assistant Professor of Medicine (Dermatology)
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| University of California, San Diego 200 W. Arbor Drive #8420, San
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| Diego, CA 92103-8420
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| Tel: 858-552-8585 ×3504 Fax: 305-675-8317 sjacob@contactderm.net;
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| seves@ucsd.edu;
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| Dermatitis. 2008 Jan-Feb;19(1):9-15.
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| Systemic contact dermatitis.
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| Jacob SE, Zapolanski T. tamar.zapolanski@gmail.com;
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| Department of Dermatology and Cutaneous Surgery, University of Miami,
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| Miami, FL, USA.
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| Systemic exposure to allergens resulting in a cutaneous eruption is
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| known as systemic contact dermatitis (SCD).
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| Once sensitization occurs, varying exposures to antigens via multiple
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| routes (including transepidermal routes, intravenous or intramuscular
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| routes, inhalation, and ingestion) can result in systemic flare.
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| This article highlights the different categories of common
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| contactants, metals, medications, and plants, exposure to which leads
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| to SCD.
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| A comprehensive approach that takes into account all possible routes
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| of exposure is essential in diagnosing SCD and in helping patients
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| successfully avoid their allergens. PMID: 18346390
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| "We present a case of a medical student who presented with
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| erythematous eczematoid plaques on her trunk and legs and fine
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| vesiculation of her scalp, 3 weeks after starting anatomy class.
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| Of note, she routinely washed her face and arms after leaving the
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| anatomy lab, but remained in her scrubs for the rest of the day.
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| Formaldehyde and Quaternium-15 positive reactions in the same patient.
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| [ photo ]"
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| "Our patient underscores the importance of appropriate patch testing
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| and education.
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| Once we identified the allergy to formaldehyde and quaternium-15, we
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| provided patient education materials regarding the common and not-so-
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| common locations of these chemicals and cross-reactors.
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| We also gave the patient information on avoidance and safe
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| alternatives (see Table 5).
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| Fortunately, with technical advances, this student completed the
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| anatomy section via electronic learning tools.
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| By avoiding formaldehyde, including anatomy lab, FRP in her shampoo
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| and cosmetics, and aspartame in her diet, this patient dramatically
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| improved.
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| As with all contact dermatitides, the mainstay of treatment for
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| allergic contact dermatitis is avoidance."
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|
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| http://www.skinandaging.com/article/5158Skin & Aging Journal
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| Skin & Aging - ISSN: 1096-0120 - Volume 13 - Issue 12_2005 -
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| December 2005 - Pages: 22 - 27
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|
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| Allergen Focus:
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| Focus on T.R.U.E. Test Allergens #21, 13 and 18:
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| Formaldehyde and Formaldehyde-Releasing Preservatives
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| -- By Sharon E. Jacob, M.D., Tace Steele, B.A., [now MD] and Georgette
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| Rodriguez, M.D., M.P.H.
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|
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| http://www.eczemacenter.org/eczema_center/meetfacultystaff.htm
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| [ photo ]
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|
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| The Eczema Center
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| Rady Children's Hospital of San Diego
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| 8010 Frost Street, Suite 602, San Diego, CA 92123
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| or call... (858) 966-6774
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|
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| Sharon E. Jacob , MD
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| Dr. Sharon E. Jacob is Assistant Clinical Professor of Pediatrics and
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| Medicine (Dermatology) at the University of California, School of
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| Medicine and Rady Children's Hospital.
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| She earned her medical degree from the Temple University, and
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| completed dermatology training at the University of Miami and advanced
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| contact dermatitis training at New York University (NYU).
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| She has been board certified in dermatology.
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| Dr. Jacob's clinical interests include atopic and contact dermatitis
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| and education.
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| She is considered a national expert on chemical sensitivities in the
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| skin and has published more than 45 journal articles, book chapters
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| and abstracts on this topic.
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| In 2005, Dr Jacob was the first to present contact dermatitis data on
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| U.S. pediatric patients to the American Contact Dermatitis Society
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| (ACDS).
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|
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| She has received an excellence in teaching award from the University
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| of Miami Dermatology and the Clinical Research Award from the ACDS.
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| She is an active reviewer for the following medical publications
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| including Journal of the American Academy of Dermatology, Pediatric
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| Dermatology, Dermatitis, and the Archives of Dermatology.
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| Dr. Jacob also serves on the medical board of the Inflammatory Skin
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| Disease Institute and the Skin and Aging Journal.
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| Dr. Jacob enjoys taking care of children and their families and is an
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| advocate for children's dermatologic health.
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| http://www.eczemacenter.org/eczema_center/index.htm
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|
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| Atopic dermatitis (AD) -- better known as eczema -- is the most common
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| chronic skin disorder seen in infants and children.
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| In fact, the prevalence of this condition has risen dramatically
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| during the last three decades.
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| Currently, 15% to 20% of children in the United States are expected to
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| experience this condition sometime during their lifetime, compared to
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| 7% around 1960.
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| The negative impact of eczema is profound and insidious.
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| It affects both the patient who suffers from it and that patient's
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| family members, and it does so on two important levels -- physical and
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| emotional.
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| Physical:
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| Inflamed, itchy rashes can involve any and all of the skin surfaces
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| and are frequently complicated by skin breakdown and bacterial, viral,
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| and fungal infections.
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| It is linked to the development of life-long allergic conditions,
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| including asthma, food allergies, and rhinitis.
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| Any level of AD is extremely uncomfortable and, at times, painful.
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| Individuals with moderate to severe disease report that eczema hugely
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| disturbs their sleep and impacts performance of daily activities,
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| including adverse effects on school, sports activities, work, and peer
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| relationships.
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| In studies, individuals with eczema reported more negative impact on
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| quality of life than those with insulin-dependent diabetes!
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| Emotional:
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| Patients and their families experience considerable emotional
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| distress, anxiety, and embarrassment because of people's response to
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| this illness.
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| In fact, the emotional scarring on both patient and family members may
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| outlast eczema's physical effects.
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| Parents especially suffer because it is difficult for children
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| experiencing this condition to understand that their parents cannot
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| make the torment go away.
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| The stress of caring for these children is even greater than parents
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| caring for a child with insulin-dependent diabetes.
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| Patients experience considerable discrimination and social isolation
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| because of this illness.
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| People often stare, shiver with disgust or step back in fear from
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| those who have this condition.
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| The end result for patients: A life-time of struggle with their sense
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| of worth and self esteem.
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| http://aad2008.omnibooksonline.com/data/papers/CRS-113-F.pdf lecture
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| with photos
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| ___________________________________________________
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|
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|
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| similar levels of daily formaldehyde and formic acid, causes of birth
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| defects, come from cigarettes, aspartame, and dark wines and liquors
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| -- folic acid protects most people: Rich Murray 2008.07.15
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| http://rmforall.blogspot.com/2008_07_01_archive.htm
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| Tuesday, July 15, 2008
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| http://groups.yahoo.com/group/aspartameNM/message/1552
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|
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|
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| http://www.divine.ca/en/health-and-wellness/articles/c_16_i_3295/5-reasons-to-quit-smoking-1.html
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| "A smoker who goes through one pack a day will smoke 7,300 cigarettes
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| a year, inhaling the equivalent of nearly 1 gram of formaldehyde
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| (yikes!)."
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|
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| That's about 2.5 mg daily formaldehyde intake for 20 cigarettes, over
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| the 2 mg USA FDA alarm level for formaldehyde in average 2 liters
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| daily drinking water, while a single 12 oz can of diet soda also
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| results in about 2 mg formaldehyde toxic products in the body,
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| including formic acid, a notorious cause of birth defects.
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|
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| Dark wines and liquors usually supply even more methanol, which the
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| body always turns into formaldehyde and formic acid -- the major cause
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| of "morning after" hangovers.
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|
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| High levels of folic acid, a safe, affordable vitamin in fruits and
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| vegetables, largely prevents formaldehyde and formic acid toxicity in
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| most people.
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| It is certain that high levels of aspartame use, above 2 liters daily
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| for months and years, must lead to chronic formaldehyde-formic acid
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| toxicity.
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|
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| Fully 11 % of aspartame is methanol -- 1,120 mg aspartame in 2 liters
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| diet soda, almost six 12-oz cans, gives 123 mg methanol (wood
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| alcohol). The methanol is immediately released into the body after
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| drinking .
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| Within hours, the liver turns much of the methanol into formaldehyde,
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| and then much of that into formic acid, both of which in time are
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| partially eliminated as carbon dioxide and water.
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|
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| However, about 30 % of the methanol remains in the body as cumulative
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| durable toxic metabolites of formaldehyde and formic acid -- 37 mg
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| daily, a gram every month, accumulating in and affecting every tissue.
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|
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| If only 10 % of the methanol is retained daily as formaldehyde, that
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| would give 12 mg daily formaldehyde accumulation -- about 60 times
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| more than the 0.2 mg from 10 % retention of the 2 mg EPA daily limit
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| for formaldehyde in drinking water.
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|
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| Bear in mind that the EPA limit for formaldehyde in drinking water is
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| 1 ppm, or 2 mg daily for a typical daily consumption of 2 liters of
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| water.
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| formaldehyde and formic acid in FEMA trailers and other sources
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| (aspartame, dark wines and liquors, tobacco smoke): Murray 2008.01.30
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| http://rmforall.blogspot.com/2008_01_01_archive.htm
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| Wednesday, January 30, 2008
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| http://groups.yahoo.com/group/aspartameNM/message/1508
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|
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| The FEMA trailers give about the same amount of formaldehyde and
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| formic acid daily as from a quart of dark wine or liquor, or two
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| quarts (6 12-oz cans) of aspartame diet soda, from their over 1 tenth
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| gram methanol impurity (one part in 10,000), which the body quickly
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| makes into formaldehyde and then formic acid -- enough to be the major
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| cause of "morning after" alcohol hangovers.
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|
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| Methanol and formaldehyde and formic acid also result from many fruits
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| and vegetables, tobacco and wood smoke, heater and vehicle exhaust,
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| household chemicals and cleaners, cosmetics, and new cars, drapes,
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| carpets, furniture, particleboard, mobile homes, buildings, leather...
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| so all these sources add up and interact with many other toxic
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| chemicals.
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|
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| opportunities re BA Magnuson, GA Burdock et al., Aspartame Safety
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| Evaluation 2007 Sept., Critical Reviews in Toxicology: Rich Murray 2008.07.11
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| http://rmforall.blogspot.com/2008_07_01_archive.htm
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| Friday, July 11, 2008
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| http://groups.yahoo.com/group/aspartameNM/message/1550
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| ___________________________________________________
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|
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|
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| "Of course, everyone chooses, as a natural priority, to enjoy peace,
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| joy, and love by helping to find, quickly share, and positively act
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| upon evidence about healthy and safe food, drink, and environment."
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|
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| Rich Murray, MA Room For All rmforall@comcast.net
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| 505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505
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|
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| http://RMForAll.blogspot.com new primary archive
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|
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| http://groups.yahoo.com/group/aspartameNM/messages
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| group with 126 members, 1,553 posts in a public archive
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|
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| http://groups.yahoo.com/group/aspartame/messages
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| group with 1,125 members, 22,826 posts in public archive
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| ___________________________________________________
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