Part of a family of hereditary motor and sensory neuropathies transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life.
This definition is at least in part based on: Anonymous (2023), Charcot-Marie-Tooth disease (English). Medical Subject Headings. U.S. National Library of Medicine.