Carotid intima-media thickness

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In medicine and cardiovascular disease, the carotid intima-media thickness (CIMT), measuring the carotid artery, is a surrogate outcome measure used in randomized controlled trials of the treatment of atherosclerosis.[1] It is suggested that "an annual increase of 0.03 mm in intima–media thickness was associated with a tripling of the rate of coronary events."[1]

The relationship between changes in carotid intima-media thickness and cardiac events is not clear.[2] A meta-analysis concludes "the modest relation between CIMT and coronary atherosclerosis most likely reflects variability in atherosclerosis development between the vascular beds rather than limitations of CIMT measurements."[3]