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Apixaban is an oral anticoagulant. Apixaban is an oral inhibitor of clotting Factor Xa inhibitor.


As of 8/2011, apixiban is not approved for use in the United States of America.





Hepatic metabolism.



Clinical use

Apixaban can prevent can prevent embolism and thrombosis during perioperative care according to randomized controlled trials of knee[1] and hip[2] surgery.

Apixaban may also reduce embolism better than warfarin in atrial fibrillation.[3] [4]

Randomized controlled trials of apixaban for atrial fibrillation.[3] [4]
Trial Patients Intervention Comparison Outcome Results
Intervention Control
5599 patients
• All had contraindications to warfarin
apixaban 5 mg twice daily aspirin 81 to 324 mg per day stroke or systemic embolism at 1.1 years 1.6% per year 3.7% per year
18,201 patients apixaban 5 mg twice daily warfarin (target INR 2.0 to 3.0 stroke or systemic embolism at 1.3 years 1.3% per year 1.6% per year

External links

The most up-to-date information about Apixaban and other drugs can be found at the following sites.


  1. Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Portman RJ (2009). "Apixaban or enoxaparin for thromboprophylaxis after knee replacement.". N Engl J Med 361 (6): 594-604. DOI:10.1056/NEJMoa0810773. PMID 19657123. Research Blogging.
  2. Lassen MR, Gallus A, Raskob GE, Pineo G, Chen D, Ramirez LM et al. (2010). "Apixaban versus enoxaparin for thromboprophylaxis after hip replacement.". N Engl J Med 363 (26): 2487-98. DOI:10.1056/NEJMoa1006885. PMID 21175312. Research Blogging.
  3. 3.0 3.1 3.2 Granger, Christopher B.; John H. Alexander, John J.V. McMurray, Renato D. Lopes, Elaine M. Hylek, Michael Hanna, Hussein R. Al-Khalidi, Jack Ansell, Dan Atar, Alvaro Avezum, M. Cecilia Bahit, Rafael Diaz, J. Donald Easton, Justin A. Ezekowitz, Greg Flaker, David Garcia, Margarida Geraldes, Bernard J. Gersh, Sergey Golitsyn, Shinya Goto, Antonio G. Hermosillo, Stefan H. Hohnloser, John Horowitz, Puneet Mohan, Petr Jansky, Basil S. Lewis, Jose Luis Lopez-Sendon, Prem Pais, Alexander Parkhomenko, Freek W.A. Verheugt, Jun Zhu, Lars Wallentin (2011-08). "Apixaban versus Warfarin in Patients with Atrial Fibrillation". New England Journal of Medicine: 110827230022006. DOI:10.1056/NEJMoa1107039. ISSN 0028-4793. Retrieved on 2011-08-28. Research Blogging. Cite error: Invalid <ref> tag; name "doi10.1056/NEJMoa1107039" defined multiple times with different content
  4. 4.0 4.1 4.2 Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S et al. (2011). "Apixaban in patients with atrial fibrillation.". N Engl J Med 364 (9): 806-17. DOI:10.1056/NEJMoa1007432. PMID 21309657. Research Blogging. Review in: Ann Intern Med. 2011 Apr 19;154(8):JC4-3