Vitamin B-12 deficiency: Difference between revisions
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Manifestations include [[pernicious anemia]] and [[subacute combined degeneration]]. | Manifestations include [[pernicious anemia]] and [[subacute combined degeneration]]. | ||
Vitamin B-12 deficiency may be combined with [[iron deficiency anemia]].<ref name="pmid15914358">{{cite journal| author=Beyan C, Kaptan K, Beyan E, Turan M| title=The platelet count/mean corpuscular hemoglobin ratio distinguishes combined iron and vitamin B12 deficiency from uncomplicated iron deficiency. | journal=Int J Hematol | year= 2005 | volume= 81 | issue= 4 | pages= 301-3 | pmid=15914358 | doi=10.1532/IJH97.E0311 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15914358 }} </ref> | |||
==Diagnosis== | ==Diagnosis== | ||
Vitamin B-12 deficiency may be an explanation for [[macrocytosis]]<ref name="pmid2341917">{{cite journal| author=Wymer A, Becker DM| title=Recognition and evaluation of red blood cell macrocytosis in the primary care setting. | journal=J Gen Intern Med | year= 1990 | volume= 5 | issue= 3 | pages= 192-7 | pmid=2341917 | doi= | pmc= | url= }} </ref> | |||
However, the MCV is not completely accurate.<ref name="pmid10757449">{{cite journal| author=Oosterhuis WP, Niessen RW, Bossuyt PM, Sanders GT, Sturk A| title=Diagnostic value of the mean corpuscular volume in the detection of vitamin B12 deficiency. | journal=Scand J Clin Lab Invest | year= 2000 | volume= 60 | issue= 1 | pages= 9-18 | pmid=10757449 | doi= | pmc= | url= }} </ref><ref name="pmid2187961">{{cite journal| author=Seward SJ, Safran C, Marton KI, Robinson SH| title=Does the mean corpuscular volume help physicians evaluate hospitalized patients with anemia? | journal=J Gen Intern Med | year= 1990 | volume= 5 | issue= 3 | pages= 187-91 | pmid=2187961 | doi=10.1007/BF02600530 | pmc= | url= }} </ref> | |||
Folic acid levels may not help.<ref name="pmid18414954">{{cite journal| author=Ashraf MJ, Cook JR, Rothberg MB| title=Clinical utility of folic acid testing for patients with anemia or dementia. | journal=J Gen Intern Med | year= 2008 | volume= 23 | issue= 6 | pages= 824-6 | pmid=18414954 | doi=10.1007/s11606-008-0615-z | pmc=PMC2517884 | url= }} </ref> | |||
Diagnosis may be especially difficult in alcoholics.<ref name="pmid3747828">{{cite journal| author=Savage D, Lindenbaum J| title=Anemia in alcoholics. | journal=Medicine (Baltimore) | year= 1986 | volume= 65 | issue= 5 | pages= 322-38 | pmid=3747828 | doi= | pmc= | url= }} </ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 10:24, 10 May 2012
In medicine, vitamin B-12 deficiency, is a "nutritional condition produced by a deficiency of Vitamin B-12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis."[1]
Manifestations include pernicious anemia and subacute combined degeneration.
Vitamin B-12 deficiency may be combined with iron deficiency anemia.[2]
Diagnosis
Vitamin B-12 deficiency may be an explanation for macrocytosis[3]
However, the MCV is not completely accurate.[4][5]
Folic acid levels may not help.[6]
Diagnosis may be especially difficult in alcoholics.[7]
References
- ↑ Anonymous (2024), Vitamin B-12 deficiency (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Beyan C, Kaptan K, Beyan E, Turan M (2005). "The platelet count/mean corpuscular hemoglobin ratio distinguishes combined iron and vitamin B12 deficiency from uncomplicated iron deficiency.". Int J Hematol 81 (4): 301-3. DOI:10.1532/IJH97.E0311. PMID 15914358. Research Blogging.
- ↑ Wymer A, Becker DM (1990). "Recognition and evaluation of red blood cell macrocytosis in the primary care setting.". J Gen Intern Med 5 (3): 192-7. PMID 2341917. [e]
- ↑ Oosterhuis WP, Niessen RW, Bossuyt PM, Sanders GT, Sturk A (2000). "Diagnostic value of the mean corpuscular volume in the detection of vitamin B12 deficiency.". Scand J Clin Lab Invest 60 (1): 9-18. PMID 10757449. [e]
- ↑ Seward SJ, Safran C, Marton KI, Robinson SH (1990). "Does the mean corpuscular volume help physicians evaluate hospitalized patients with anemia?". J Gen Intern Med 5 (3): 187-91. DOI:10.1007/BF02600530. PMID 2187961. Research Blogging.
- ↑ Ashraf MJ, Cook JR, Rothberg MB (2008). "Clinical utility of folic acid testing for patients with anemia or dementia.". J Gen Intern Med 23 (6): 824-6. DOI:10.1007/s11606-008-0615-z. PMID 18414954. PMC PMC2517884. Research Blogging.
- ↑ Savage D, Lindenbaum J (1986). "Anemia in alcoholics.". Medicine (Baltimore) 65 (5): 322-38. PMID 3747828. [e]