View source for U1 small nuclear ribonucleoprotein/Definition

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A nuclear RNA-protein complex that plays a role in [[RNA]] processing. In the nucleoplasm, the U1 snRNP along with other [[small nuclear ribonucleoproteins]] (U2, U4-U6, and U5) assemble into [[spliceosome]]s that remove [[intron]]s from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.<noinclude>{{DefMeSH}}</noinclude>