Thrombocytopenia: Difference between revisions

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imported>Robert Badgett
imported>Robert Badgett
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A [[systematic review]] has identified common causes of drug-induced thrombocytopenia.<ref name="pmid9867731">{{cite journal |author=George JN, Raskob GE, Shah SR, ''et al'' |title=Drug-induced thrombocytopenia: a systematic review of published case reports |journal=Ann. Intern. Med. |volume=129 |issue=11 |pages=886–90 |year=1998 |pmid=9867731 |doi=|url=http://www.annals.org/cgi/content/full/129/11_Part_1/886}}</ref>
A [[systematic review]] has identified common causes of drug-induced thrombocytopenia.<ref name="pmid9867731">{{cite journal |author=George JN, Raskob GE, Shah SR, ''et al'' |title=Drug-induced thrombocytopenia: a systematic review of published case reports |journal=Ann. Intern. Med. |volume=129 |issue=11 |pages=886–90 |year=1998 |pmid=9867731 |doi=|url=http://www.annals.org/cgi/content/full/129/11_Part_1/886}}</ref>


Drug-induced thrombocytopenia maybe immune medicated.<ref name="pmid17687133">{{cite journal |author=Aster RH, Bougie DW |title=Drug-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=357 |issue=6 |pages=580–7 |year=2007 |pmid=17687133 |doi=10.1056/NEJMra066469|url=http://content.nejm.org/cgi/content/full/357/6/580}}</ref> [[Heparin-induced thrombocytopenia]] (HIT) is caused by anti-platelet antibodies.<ref name="pmid16928996">{{cite journal |author=Arepally GM, Ortel TL |title=Clinical practice. Heparin-induced thrombocytopenia |journal=N. Engl. J. Med. |volume=355 |issue=8 |pages=809–17 |year=2006 |pmid=16928996 |doi=10.1056/NEJMcp052967|url=http://content.nejm.org/cgi/content/full/355/8/809}}</ref> Other drugs include vancomycin
Drug-induced thrombocytopenia maybe immune medicated.<ref name="pmid17687133">{{cite journal |author=Aster RH, Bougie DW |title=Drug-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=357 |issue=6 |pages=580–7 |year=2007 |pmid=17687133 |doi=10.1056/NEJMra066469|url=http://content.nejm.org/cgi/content/full/357/6/580}}</ref> [[Heparin-induced thrombocytopenia]] (HIT) is caused by anti-platelet antibodies.<ref name="pmid16928996">{{cite journal |author=Arepally GM, Ortel TL |title=Clinical practice. Heparin-induced thrombocytopenia |journal=N. Engl. J. Med. |volume=355 |issue=8 |pages=809–17 |year=2006 |pmid=16928996 |doi=10.1056/NEJMcp052967|url=http://content.nejm.org/cgi/content/full/355/8/809}}</ref> Other drugs include [[vancomycin]]
<ref name="pmid17329697">{{cite journal |author=Von Drygalski A, Curtis BR, Bougie DW, ''et al'' |title=Vancomycin-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=356 |issue=9 |pages=904–10 |year=2007 |pmid=17329697 |doi=10.1056/NEJMoa065066}}</ref> and oxaliplatin<ref name="pmid12859182">{{cite journal |author=Dold FG, Mitchell EP |title=Sudden-onset thrombocytopenia with oxaliplatin |journal=Ann. Intern. Med. |volume=139 |issue=2 |pages=E156 |year=2003 |pmid=12859182 |doi=|url=http://www.annals.org/cgi/content/full/139/2/W-59}}</ref>
<ref name="pmid17329697">{{cite journal |author=Von Drygalski A, Curtis BR, Bougie DW, ''et al'' |title=Vancomycin-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=356 |issue=9 |pages=904–10 |year=2007 |pmid=17329697 |doi=10.1056/NEJMoa065066}}</ref> and oxaliplatin<ref name="pmid12859182">{{cite journal |author=Dold FG, Mitchell EP |title=Sudden-onset thrombocytopenia with oxaliplatin |journal=Ann. Intern. Med. |volume=139 |issue=2 |pages=E156 |year=2003 |pmid=12859182 |doi=|url=http://www.annals.org/cgi/content/full/139/2/W-59}}</ref>


Revision as of 14:17, 6 January 2008

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Thrombocytopenia is a decrease in the platelet count. The half-life of a platelet in a normal person is about 4 days.[1]

Cause/etiology

Medications

A systematic review has identified common causes of drug-induced thrombocytopenia.[2]

Drug-induced thrombocytopenia maybe immune medicated.[3] Heparin-induced thrombocytopenia (HIT) is caused by anti-platelet antibodies.[4] Other drugs include vancomycin [5] and oxaliplatin[6]

References

  1. ↑ Fritz E, Ludwig H, Scheithauer W, Sinzinger H (1986). "Shortened platelet half-life in multiple myeloma". Blood 68 (2): 514–20. PMID 3730614. [e]
  2. ↑ George JN, Raskob GE, Shah SR, et al (1998). "Drug-induced thrombocytopenia: a systematic review of published case reports". Ann. Intern. Med. 129 (11): 886–90. PMID 9867731. [e]
  3. ↑ Aster RH, Bougie DW (2007). "Drug-induced immune thrombocytopenia". N. Engl. J. Med. 357 (6): 580–7. DOI:10.1056/NEJMra066469. PMID 17687133. Research Blogging.
  4. ↑ Arepally GM, Ortel TL (2006). "Clinical practice. Heparin-induced thrombocytopenia". N. Engl. J. Med. 355 (8): 809–17. DOI:10.1056/NEJMcp052967. PMID 16928996. Research Blogging.
  5. ↑ Von Drygalski A, Curtis BR, Bougie DW, et al (2007). "Vancomycin-induced immune thrombocytopenia". N. Engl. J. Med. 356 (9): 904–10. DOI:10.1056/NEJMoa065066. PMID 17329697. Research Blogging.
  6. ↑ Dold FG, Mitchell EP (2003). "Sudden-onset thrombocytopenia with oxaliplatin". Ann. Intern. Med. 139 (2): E156. PMID 12859182. [e]

External links

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