Stress (physiology): Difference between revisions
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==Stress and the immune system== | ==Stress and the immune system== | ||
The major [[hormone|hormones]] that are produced during stress are the [[adrenal gland|adrenal glands']] secretion of catecholamines, glucocorticoids and DHEA. The major glucocorticoid, [[cortisol]] (a prednisone-like anti-inflammatory steroid) reduces the [[immune system|immune]] response. In fact, "catecholamines and cortisol can both be immunosuppressive if chronically elevated... In contrast, DHEA is a precursor to sex hormones and is immune enhancing. Our own [[in vitro]] studies have shown that cortisol suppresses neutrophil function, and this can be overcome by coincubation with DHEA sulfate."(reference for quote:Phillips AC. Burns VE. Lord JM. Stress and exercise: Getting the balance right for aging immunity. [Review] [24 refs] Exercise & Sport Sciences Reviews. 35(1):35-9, 2007 Jan. UI: 17211192) | The major [[hormone|hormones]] that are produced during stress are the [[adrenal gland|adrenal glands']] secretion of catecholamines, glucocorticoids and DHEA. The major glucocorticoid, [[cortisol]] (a prednisone-like anti-inflammatory steroid) reduces the [[immune system|immune]] response. In fact, "catecholamines and cortisol can both be immunosuppressive if chronically elevated... In contrast, DHEA is a precursor to sex hormones and is immune enhancing. Our own [[in vitro]] studies have shown that cortisol suppresses neutrophil function, and this can be overcome by coincubation with DHEA sulfate."(reference for quote:Phillips AC. Burns VE. Lord JM. Stress and exercise: Getting the balance right for aging immunity. [Review] [24 refs] Exercise & Sport Sciences Reviews. 35(1):35-9, 2007 Jan. UI: 17211192) | ||
Revision as of 22:17, 14 November 2007
Stress and the immune system
The major hormones that are produced during stress are the adrenal glands' secretion of catecholamines, glucocorticoids and DHEA. The major glucocorticoid, cortisol (a prednisone-like anti-inflammatory steroid) reduces the immune response. In fact, "catecholamines and cortisol can both be immunosuppressive if chronically elevated... In contrast, DHEA is a precursor to sex hormones and is immune enhancing. Our own in vitro studies have shown that cortisol suppresses neutrophil function, and this can be overcome by coincubation with DHEA sulfate."(reference for quote:Phillips AC. Burns VE. Lord JM. Stress and exercise: Getting the balance right for aging immunity. [Review] [24 refs] Exercise & Sport Sciences Reviews. 35(1):35-9, 2007 Jan. UI: 17211192)