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...non-steroidal anti-inflammatory agent]] (NSAID) that inhibits the enzyme [[cyclooxygenase]] necessary for the formation of [[prostaglandin]]s and other autacoids. It

'''Rofecoxib''' is a [[cyclooxygenase 2 inhibitors|cyclooxygenase 2 inhibitor]] drug used as an analgesic until it was voluntarily withdrawn

{{r|Cyclooxygenase}}

===Cyclooxygenase-1 blockers=== Cyclooxygenase-1 blockers include [[aspirin]].

...l anti-inflammatory drugs]] (NSAIDS). It is thought to be a nonselective [[cyclooxygenase]] (COX) inhibitor, and, like other NSAIDS, may lead to discomfort and ulcer

* The relationship between [[colorectal cancer]] and [[cyclooxygenase 2 inhibitor]]s.<ref name="pmid17522398">{{cite journal| author=Chan AT, Ogi

.... They act by blocking the synthesis of [[prostaglandin]]s by inhibiting [[cyclooxygenase]]s, which convert arachidonic acid to cyclic endoperoxides, precursors of p ...inhibit some cancers, such as [[squamous cell carcinoma]] that expresses [[cyclooxygenase 1]]. Nevertheless, they can cause sudden and life-threatening reactions, su

...but unlike acetylsalicylic acid, salsalate does not irreversibly inhibit [[cyclooxygenase]] and thus is not an [[anti-platelet agent]].

{{r|Cyclooxygenase 2 inhibitors}}

...nflammatory drugs]] may have a role in prevention. Some of the selective [[cyclooxygenase 2 inhibitors]] may have even stronger preventive effect, but these also car

...arachidonic acid, leading to diminished [[eicosanoid]] production. The [[cyclooxygenase]] (both COX-1 and COX-2) expression is also suppressed, potentiating the ef

...anti-inflammatory and antipyretic properties and acts as an inhibitor of [[cyclooxygenase]] which results in the inhibition of the biosynthesis of [[prostaglandin]]s

*[[Aspirin]] inhibits [[cyclooxygenase]]-1, preventing positive feedback ...tance, [[aspirin]] irreversibly disrupts platelet function by inhibiting [[cyclooxygenase]]-1 and -2 (COX1 and COX2), and hence normal hemostasis; normal platelet fu

Acetaminophen inhibits [[cyclooxygenase]]-1 (COX-1) and [[cyclooxygenase]]-2 (COX-2) indirectly through a hypothesized yet unknown enzyme called CO

...gel BM, Targownik L, Dulai GS, Gralnek IM |title=The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis |journal=Ann.

...journal |author=De Smet BD ''et al.'' |title=Over and under-utilization of cyclooxygenase-2 selective inhibitors by primary care physicians and specialists: the tort

...n may reduce mortality among patients whose tumor overexpress the enzyme [[cyclooxygenase 2]] according to a [[cohort study]].<ref name="pmid19671906">{{cite journal ...r=Soumaoro LT, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K| title=Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorect

...studies<ref>Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain. Christopher D Toscano, Vinaykumar V Prabhu, Robert

...studies<ref>Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain. Christopher D Toscano, Vinaykumar V Prabhu, Robert

Some of the tumors express [[cyclooxygenase-2]], so a selective [[NSAID]], such as [[meloxicam]], offers both pain reli