Platelet glycoprotein GPIIb-IIIa complex: Difference between revisions
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** [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&TermToSearch=3674 Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)] | ** [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&TermToSearch=3674 Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)] | ||
* [http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?l273800 OMIM Gene map] | * [http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?l273800 OMIM Gene map] | ||
Revision as of 20:34, 22 January 2008
Platelet Glycoprotein GPIIb-IIIa Complex is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."[1]
Role in medicine
A deficiency of GPIIb-IIIa is the cause of Glanzman Thrombasthenia, which causes a prolonged bleeding time.
Antibodies to GPIIb-IIIa is the cause of most cases of chronic idiopathic thrombocytopenic purpura (ITP).
Antibodies to immune complexes of GPIIb-IIIa and various drugs underly many cases of drug-induced immune thrombocytopenia.[2]
Glycoprotein IIb/IIIa inhibitors are platelet aggregation inhibitors used to treat cardiovascular diseases.
References
- ↑ Anonymous. Platelet Glycoprotein GPIIb-IIIa Complex. National Library of Medicine. Retrieved on 2008-01-10.
- ↑ Aster RH, Bougie DW (2007). "Drug-induced immune thrombocytopenia". N. Engl. J. Med. 357 (6): 580–7. DOI:10.1056/NEJMra066469. PMID 17687133. Research Blogging.