Penicillin V

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penicillin V
IUPAC name: see chemistry section
Synonyms: phenoxymethyl penicillin'
Formula: C16H18N2O5S

 Uses: antibiotic drug

 Properties: beta-lactam

 Hazards: see drug interactions

Mass (g/mol): CAS #:
350.3895 87-08-1



Penicillin V, or phenoxymethyl penicillin, is a broad-spectrum, beta-lactam-based antibiotic used to treat mild to severe infections due to gram-positive bacteria. It is used to treat dental, hear, middle ear, respiratory tract and skin infections, and can also treat rheumatic and scarlet fevers.

Mechanism of action

Like other penicillin-like drugs, penicillin V works by binding to specific penicillin-binding proteins in bacterial cell walls and blocking the final cross-linking step in the synthesis of bacterial cell walls. This induces autolysis of the bactertial cells by autolysins.

Chemistry

Penicillin V is stable against degradation by beta-lactamases, including penicillinases, and cephalosporinases. Its IUPAC chemical name is (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-(phenoxy)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and it has molecular formula C16H18N2O5S (MM = 350.3895 g/mol).

Drug interactions

Tetracycline and its derivatives demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline, rolitetracycline, and tetracycline are antagonists of penicillins. The effects of oral contraceptives, including [[ethinyl estradiol] and mestranol are decreased when using penicillin. Penicillins increases the effect and toxicity of methotrexate.[1]

Synonyms and brand names

synonyms

  • Fenossimetilpenicillina
  • Fenoximetilpenicilina
  • Penicillin Phenoxymethyl
  • Penicillin V Potassium
  • Phenoxymethylpenicillinic Acid
  • Phenoxymethylpenicillinic Acid Potassium Salt
  • Phenoxymethylpenicillin Potassium
  • Phenoxymethylenepenicillinic Acid
  • Phenoxymethyl Penicillin
  • Phenoximethylpenicillinum

Brand names

  • Acipen V®
  • Apopen®
  • Beepen-Vk®
  • Beromycin®
  • Betapen-Vk®
  • Calcipen®
  • Compocillin V®
  • Crystapen V®
  • Distaquaine V®
  • Eskacillian V®
  • Eskacillin V®
  • Fenacilin®
  • Fenospen®
  • Fenoxypen®
  • Ledercillin Vk®

Brand names

  • Meropenin®
  • Oracillin®
  • Oratren®
  • Ospen®
  • Pen-Oral®
  • Pen-V®
  • Pen-Vee®
  • Pen-Vee K®
  • Penapar-Vk®
  • Penicillin Vk®
  • Penicillin-Vk®
  • Pfizerpen Vk®
  • Phenocillin®
  • Phenomycilline®
  • Phenopenicillin®

Brand Names

  • Robicillin®
  • Rocilin®
  • Stabicillin®
  • Uticillin Vk®
  • V-Cil®
  • V-Cillin®
  • V-Cillin K®
  • V-Cylina®
  • V-Cyline®
  • V-Tablopen®
  • Vebecillin®
  • Veetids®
  • Veetids '125'®
  • Veetids '250'®
  • Veetids '500'®

External links