Isotopomer: Difference between revisions
imported>Paul Wormer (New page: {{subpages}} '''Isotopomers''' are isomers having the same number of each isotopic atom but differing in their positions. The term is a contraction of 'isotopic isomer'. Isotopomers c...) |
imported>David E. Volk mNo edit summary |
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==External link== | ==External link== | ||
[http://goldbook.iupac.org/I03352.html IUPAC Goldbook] | [http://goldbook.iupac.org/I03352.html IUPAC Goldbook] | ||
== Uses == | |||
Isotopomers are useful agents for various [[mass spectroscopy]] techniques in which isotopically-labeled tags are attached to other molecules of interest. The iTRAQ method is one example, in which either 4 or 8 chemically equivalent chemical tags are added to different protein samples. Although the overall mass of the tags are identical, the cleavage products of the tags into smaller units create either 4 or 8 different masses so that peptides from each sample can be directly compared to the others to determine relative concentrations. | |||
Revision as of 11:05, 11 March 2011
Isotopomers are isomers having the same number of each isotopic atom but differing in their positions. The term is a contraction of 'isotopic isomer'. Isotopomers can be either constitutional isomers (e.g. CH2DCH=O and CH3CD=O) or isotopic stereoisomers [e.g. (R)- and (S)-CH3CHDOH or (Z)- and (E)-CH3CH=CHD].
External link
Uses
Isotopomers are useful agents for various mass spectroscopy techniques in which isotopically-labeled tags are attached to other molecules of interest. The iTRAQ method is one example, in which either 4 or 8 chemically equivalent chemical tags are added to different protein samples. Although the overall mass of the tags are identical, the cleavage products of the tags into smaller units create either 4 or 8 different masses so that peptides from each sample can be directly compared to the others to determine relative concentrations.