Interleukin: Difference between revisions
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imported>Howard C. Berkowitz No edit summary |
imported>Howard C. Berkowitz No edit summary |
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'''Interleukins''' are [[cytokines]] that are made by one leukocyte, acting on other leukocytes). | '''Interleukins''' are [[cytokines]] that are made by one leukocyte, acting on other leukocytes). | ||
{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
! Name(s) | ! Name(s) | ||
| Line 11: | Line 10: | ||
| Il-1a, IL-1b | | Il-1a, IL-1b | ||
| [[monocyte]]s, [[macrophage]]s, [[lymphocyte#B-lymphocyte|B-lymphocytes]], DC | | [[monocyte]]s, [[macrophage]]s, [[lymphocyte#B-lymphocyte|B-lymphocytes]], DC | ||
| | | T<sub>H</sub> cells, B cells, NK cells, general inflammation-susceptible | ||
| | | T<sub>H</sub> cell co-stimulation, [[lymphocyte#B-lymphocyte|B-lymphocyte]] maturation and proliferation, NK cell activation, general inflammation | ||
|- | |- | ||
| IL-2 | | IL-2 | ||
| Th1 cells | | Th1 cells | ||
| activated [[lymphocyte#T-lymphocyte|T-]] and [[lymphocyte#B-lymphocyte|B-lymphocytes]], | | activated [[lymphocyte#T-lymphocyte|T-]] and [[lymphocyte#B-lymphocyte|B-lymphocytes]], [[natural killer cell]]s | ||
| growth, proliferation, activation | | growth, proliferation, activation | ||
|- | |- | ||
| IL-3 | | IL-3 | ||
| | | T<sub>H</sub> cells, NK cells | ||
|[[stem cell]]s, [[mast cell]]s | |[[stem cell]]s, [[mast cell]]s | ||
|stem cell growth and differentiation, mast | |stem cell growth and differentiation, [[mast cell]]s growth and [[histamine]] release | ||
|- | |- | ||
| IL-4 | | IL-4 | ||
| | | T<sub>H</sub>2 cells | ||
| activated B cells, macrophages, T cells | | activated B cells, macrophages, T cells | ||
| [[Immunoglobulin#Immuniglobulin G|IgG<sub>1</sub>]] and [[Immunoglobulin#Immuniglobulin A|IgE synthesis]] ,macrophage [[Major histocompatibility complex|MHC Class II]], T cell growth, B cell growth | | [[Immunoglobulin#Immuniglobulin G|IgG<sub>1</sub>]] and [[Immunoglobulin#Immuniglobulin A|IgE synthesis]] ,macrophage [[Major histocompatibility complex|MHC Class II]], T cell growth, B cell growth | ||
|- | |- | ||
| IL-5 | | IL-5 | ||
| | | T<sub>H</sub>2 cells | ||
| activated B | | activated B lymphocytes | ||
| proliferation and differentiation, [[Immunoglobulin#Immuniglobulin A|IgA synthesis]] | | proliferation and differentiation, [[Immunoglobulin#Immuniglobulin A|IgA synthesis]] | ||
|- | |- | ||
| IL-6 | | IL-6 | ||
| monocytes, macrophages, T | | monocytes, macrophages, T<sub>H</sub>2 lymphocytes, stromal cells | ||
| activated B cells, plasma cells, stem cells, | | activated B cells, plasma cells, stem cells, | ||
|differentiate B lymphocytes | |differentiate B lymphocytes into plasma cells, promotes [[immunoglobulin]] synthesis by B lymphocytes, [[plasma cell]] antibody secretion, [[stem cell]] differentiation, general [[acute phase response]], increases [[hepcidin]] secretion | ||
|- | |- | ||
| IL-7 | | IL-7 | ||
| Line 47: | Line 46: | ||
| macrophages and endothelial cells | | macrophages and endothelial cells | ||
| neutrophils | | neutrophils | ||
|chemotaxic attraction of | |chemotaxic attraction of [[neutrophil]]s | ||
|- | |- | ||
| IL-10 | | IL-10 | ||
| Line 63: | Line 62: | ||
| | | | ||
| Similar to IL-4 | | Similar to IL-4 | ||
Latest revision as of 19:54, 31 January 2010
Interleukins are cytokines that are made by one leukocyte, acting on other leukocytes).
| Name(s) | Source | Target | Function |
|---|---|---|---|
| Il-1a, IL-1b | monocytes, macrophages, B-lymphocytes, DC | TH cells, B cells, NK cells, general inflammation-susceptible | TH cell co-stimulation, B-lymphocyte maturation and proliferation, NK cell activation, general inflammation |
| IL-2 | Th1 cells | activated T- and B-lymphocytes, natural killer cells | growth, proliferation, activation |
| IL-3 | TH cells, NK cells | stem cells, mast cells | stem cell growth and differentiation, mast cells growth and histamine release |
| IL-4 | TH2 cells | activated B cells, macrophages, T cells | IgG1 and IgE synthesis ,macrophage MHC Class II, T cell growth, B cell growth |
| IL-5 | TH2 cells | activated B lymphocytes | proliferation and differentiation, IgA synthesis |
| IL-6 | monocytes, macrophages, TH2 lymphocytes, stromal cells | activated B cells, plasma cells, stem cells, | differentiate B lymphocytes into plasma cells, promotes immunoglobulin synthesis by B lymphocytes, plasma cell antibody secretion, stem cell differentiation, general acute phase response, increases hepcidin secretion |
| IL-7 | marrow and thymus stroma | stem cells | differentiation |
| IL-8 | macrophages and endothelial cells | neutrophils | chemotaxic attraction of neutrophils |
| IL-10 | Th2 cells | macrophages, B-cells | downregulate cytokine production by macrophages, activate B-lymphocytes |
| IL-12 | macrophages, B cells | activated Tc cells, natural killer cells | In combination with IL-2, differentiate Tc cells into CTL; activate NK |
| IL-13 | TH2 cells | Similar to IL-4 |