Hyperuricemia: Difference between revisions

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In [[medicine]], '''hyperuricemia''' is "excessive [[uric acid]] or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined ([[Lesch-Nyhan Syndrome]]). It is associated with [[hypertension]] and [[gout]]."<ref>{{MeSH}}</ref>
In [[medicine]], '''hyperuricemia''' is "excessive [[uric acid]] or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined ([[Lesch-Nyhan Syndrome]]). It is associated with [[hypertension]] and [[gout]]."<ref>{{MeSH}}</ref>


Hyperuricemia may<ref name="pmid10815083">{{cite journal |author=Fang J, Alderman MH |title=Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey |journal=JAMA |volume=283 |issue=18 |pages=2404–10 |year=2000 |month=May |pmid=10815083 |doi= |url=http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=10815083 |issn=}}</ref><ref name="pmid17698728">{{cite journal |author=Choi HK, Curhan G |title=Independent impact of gout on mortality and risk for coronary heart disease |journal=Circulation |volume=116 |issue=8 |pages=894–900 |year=2007 |month=August |pmid=17698728 |doi=10.1161/CIRCULATIONAHA.107.703389 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=17698728 |issn=}}</ref> or may not<ref name="pmid10391820">{{cite journal |author=Culleton BF, Larson MG, Kannel WB, Levy D |title=Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study |journal=Ann. Intern. Med. |volume=131 |issue=1 |pages=7–13 |year=1999 |month=July |pmid=10391820 |doi= |url=http://www.annals.org/cgi/pmidlookup?view=long&pmid=10391820 |issn=}}</ref> be associated with [[vascular disease]] and [[chronic kidney disease]]<ref name="pmid16377385">{{cite journal |author=Siu YP, Leung KT, Tong MK, Kwan TH |title=Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level |journal=Am. J. Kidney Dis. |volume=47 |issue=1 |pages=51–9 |year=2006 |month=January |pmid=16377385 |doi=10.1053/j.ajkd.2005.10.006 |url=http://linkinghub.elsevier.com/retrieve/pii/S0272-6386(05)01518-0 |issn=}}</ref>.<ref name="pmid18946066">{{cite journal |author=Feig DI, Kang DH, Johnson RJ |title=Uric acid and cardiovascular risk |journal=N. Engl. J. Med. |volume=359 |issue=17 |pages=1811–21 |year=2008 |month=October |pmid=18946066 |doi=10.1056/NEJMra0800885 |url=http://content.nejm.org/cgi/content/full/359/17/1811 |issn=}}</ref> if hyperuricemia is associated with vascular disease, a [[meta-analysis]] suggests that the strength of association is unlikely to be large enough for the presence of hyperuricemia to help in the detection of vascular disease.<ref name="pmid15783260">{{cite journal |author=Wheeler JG, Juzwishin KD, Eiriksdottir G, Gudnason V, Danesh J |title=Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis |journal=PLoS Med. |volume=2 |issue=3 |pages=e76 |year=2005 |month=March |pmid=15783260 |pmc=1069667 |doi=10.1371/journal.pmed.0020076 |url=http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0020076 |issn=}}</ref>
Hyperuricemia may<ref name="pmid10815083">{{cite journal |author=Fang J, Alderman MH |title=Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey |journal=JAMA |volume=283 |issue=18 |pages=2404–10 |year=2000 |month=May |pmid=10815083 |doi= |url=http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=10815083 |issn=}}</ref><ref name="pmid17698728">{{cite journal |author=Choi HK, Curhan G |title=Independent impact of gout on mortality and risk for coronary heart disease |journal=Circulation |volume=116 |issue=8 |pages=894–900 |year=2007 |month=August |pmid=17698728 |doi=10.1161/CIRCULATIONAHA.107.703389 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=17698728 |issn=}}</ref> or may not<ref name="pmid10391820">{{cite journal |author=Culleton BF, Larson MG, Kannel WB, Levy D |title=Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study |journal=Ann. Intern. Med. |volume=131 |issue=1 |pages=7–13 |year=1999 |month=July |pmid=10391820 |doi= |url=http://www.annals.org/cgi/pmidlookup?view=long&pmid=10391820 |issn=}}</ref> be associated with [[vascular disease]] and [[chronic kidney disease]]<ref name="pmid16377385">{{cite journal |author=Siu YP, Leung KT, Tong MK, Kwan TH |title=Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level |journal=Am. J. Kidney Dis. |volume=47 |issue=1 |pages=51–9 |year=2006 |month=January |pmid=16377385 |doi=10.1053/j.ajkd.2005.10.006 |url=http://linkinghub.elsevier.com/retrieve/pii/S0272-6386(05)01518-0 |issn=}}</ref>.<ref name="pmid18946066">{{cite journal |author=Feig DI, Kang DH, Johnson RJ |title=Uric acid and cardiovascular risk |journal=N. Engl. J. Med. |volume=359 |issue=17 |pages=1811–21 |year=2008 |month=October |pmid=18946066 |doi=10.1056/NEJMra0800885 |url=http://content.nejm.org/cgi/content/full/359/17/1811 |issn=}}</ref> If hyperuricemia is associated with vascular disease, a [[meta-analysis]] suggests that the strength of association is unlikely to be large enough for the presence of hyperuricemia to help in the prediction of vascular disease.<ref name="pmid15783260">{{cite journal |author=Wheeler JG, Juzwishin KD, Eiriksdottir G, Gudnason V, Danesh J |title=Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis |journal=PLoS Med. |volume=2 |issue=3 |pages=e76 |year=2005 |month=March |pmid=15783260 |pmc=1069667 |doi=10.1371/journal.pmed.0020076 |url=http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0020076 |issn=}}</ref>


==References==
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In medicine, hyperuricemia is "excessive uric acid or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (Lesch-Nyhan Syndrome). It is associated with hypertension and gout."[1]

Hyperuricemia may[2][3] or may not[4] be associated with vascular disease and chronic kidney disease[5].[6] If hyperuricemia is associated with vascular disease, a meta-analysis suggests that the strength of association is unlikely to be large enough for the presence of hyperuricemia to help in the prediction of vascular disease.[7]

References

  1. ↑ Anonymous (2024), Hyperuricemia (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Fang J, Alderman MH (May 2000). "Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey". JAMA 283 (18): 2404–10. PMID 10815083. [e]
  3. ↑ Choi HK, Curhan G (August 2007). "Independent impact of gout on mortality and risk for coronary heart disease". Circulation 116 (8): 894–900. DOI:10.1161/CIRCULATIONAHA.107.703389. PMID 17698728. Research Blogging.
  4. ↑ Culleton BF, Larson MG, Kannel WB, Levy D (July 1999). "Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study". Ann. Intern. Med. 131 (1): 7–13. PMID 10391820. [e]
  5. ↑ Siu YP, Leung KT, Tong MK, Kwan TH (January 2006). "Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level". Am. J. Kidney Dis. 47 (1): 51–9. DOI:10.1053/j.ajkd.2005.10.006. PMID 16377385. Research Blogging.
  6. ↑ Feig DI, Kang DH, Johnson RJ (October 2008). "Uric acid and cardiovascular risk". N. Engl. J. Med. 359 (17): 1811–21. DOI:10.1056/NEJMra0800885. PMID 18946066. Research Blogging.
  7. ↑ Wheeler JG, Juzwishin KD, Eiriksdottir G, Gudnason V, Danesh J (March 2005). "Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis". PLoS Med. 2 (3): e76. DOI:10.1371/journal.pmed.0020076. PMID 15783260. PMC 1069667. Research Blogging.
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