Fluconazole: Difference between revisions
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'''Fluconazole''', IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat [[oropharyngeal]] (vaginal) [[candidiasis]] and [[cryptococcal meningitis]] in AIDS. Fluconazole interacts with the enzyme [[14-α demethylase]] that converts [[lanosterol]] to [[ergosterol]]. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage. | '''Fluconazole''', IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat [[oropharyngeal]] (vaginal) [[candidiasis]] and [[cryptococcal meningitis]] in AIDS. Fluconazole interacts with the enzyme [[14-α demethylase]] that converts [[lanosterol]] to [[ergosterol]]. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage. | ||
Revision as of 08:03, 8 June 2009
Fluconazole, IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat oropharyngeal (vaginal) candidiasis and cryptococcal meningitis in AIDS. Fluconazole interacts with the enzyme 14-α demethylase that converts lanosterol to ergosterol. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage.
Brand Names
- Biocanol®
- Biozolene®
- Diflucan®
- Elazor®
- Flucazol®
- Flucostat®
- Flukezol®
- Flunizol®
- Flusol®
- Pritenzol®
- Triflucan®
External Links
The most up-to-date information about Fluconazole and other drugs can be found at the following sites.
- Fluconazole - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Fluconazole - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Fluconazole - Detailed information from DrugBank.