Fibrate
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In medicine, fibrates are antilipemic agents for treating hyperlipidemia. Fibrates lower triglycerides by being agonists of peroxisome proliferator-activated receptor alpha (PPAR alpha)[1] Examples include:
Clinical use
A systematic review of randomized controlled trials of fibrates concluded "In addition to improving lipid profiles, fibrates are associated with an important decrease in nonfatal myocardial infarction, but do not substantially affect all-cause mortality."[2]
References
- ↑ Barter PJ, Rye KA (2006). "Cardioprotective properties of fibrates: which fibrate, which patients, what mechanism?". Circulation 113 (12): 1553-5. DOI:10.1161/CIRCULATIONAHA.105.620450. PMID 16567579. Research Blogging.
- ↑ Abourbih S, Filion KB, Joseph L, Schiffrin EL, Rinfret S, Poirier P et al. (2009). "Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review.". Am J Med 122 (10): 962.e1-8. DOI:10.1016/j.amjmed.2009.03.030. PMID 19698935. Research Blogging.