Cyclooxygenase inhibitor: Difference between revisions
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In [[pharmacology]], '''cyclooxygenase inhibitors''' are "compounds or agents that combine with [[cyclooxygenase]] (prostaglandin-endoperoxide synthases) and thereby prevent its substrate-enzyme combination with [[arachidonic acid]] and the formation of [[eicosanoid]]s, [[prostaglandin]]s, and [[thromboxane]]s."<ref>{{MeSH}}</ref> THey are prescribed to relieve pain, inflammation, and smooth muscle contractions (e.g., menstrual cramps). | In [[pharmacology]], '''cyclooxygenase inhibitors''' are "compounds or agents that combine with [[cyclooxygenase]] (prostaglandin-endoperoxide synthases) and thereby prevent its substrate-enzyme combination with [[arachidonic acid]] and the formation of [[eicosanoid]]s, [[prostaglandin]]s, and [[thromboxane]]s."<ref>{{MeSH}}</ref> THey are prescribed to relieve pain, inflammation, and smooth muscle contractions (e.g., menstrual cramps). | ||
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[[Cyclooxygenase 2 inhibitor]] are selective for [[cyclooxygenase-2]]. Most selective cyclooxygenase 2 inhibitors have been withdrawn from the market because they increase the risk of adverse cardiac events. Their attraction is that they cause much less gastric irritation that nonselective inhibitors, because cyclooxygenase 1 suppresses the production of protective gastric mucus. | [[Cyclooxygenase 2 inhibitor]] are selective for [[cyclooxygenase-2]]. Most selective cyclooxygenase 2 inhibitors have been withdrawn from the market because they increase the risk of adverse cardiac events. Their attraction is that they cause much less gastric irritation that nonselective inhibitors, because cyclooxygenase 1 suppresses the production of protective gastric mucus. | ||
==Other drugs affecting arachidonic acid== | ==Other drugs affecting arachidonic acid== | ||
[[Leukotriene inhibitor]]s suppress another path starting with arachidonic acid. They are primarily used fr he treatment of asthma, as leukotrienes are part of late-phase inflammatory reactions, | [[Leukotriene inhibitor]]s suppress another path starting with arachidonic acid. They are primarily used fr he treatment of asthma, as leukotrienes are part of late-phase inflammatory reactions, even though cyclooxygenase inhibitors can aggravate asthna. In addition, they can also relieve pain. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 12:25, 28 December 2010
In pharmacology, cyclooxygenase inhibitors are "compounds or agents that combine with cyclooxygenase (prostaglandin-endoperoxide synthases) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes."[1] THey are prescribed to relieve pain, inflammation, and smooth muscle contractions (e.g., menstrual cramps).
They do not affect blood coagulation as does aspirin and offer antiinflammatory activity that acetaminophen does not.
Classification
Non-selective inhibitors of cyclooxygenase
Non-selective inhibitors of cyclooxygenase are called non-steroidal anti-inflammatory agents.
Cyclooxygenase 2 inhibitors
Cyclooxygenase 2 inhibitor are selective for cyclooxygenase-2. Most selective cyclooxygenase 2 inhibitors have been withdrawn from the market because they increase the risk of adverse cardiac events. Their attraction is that they cause much less gastric irritation that nonselective inhibitors, because cyclooxygenase 1 suppresses the production of protective gastric mucus.
Other drugs affecting arachidonic acid
Leukotriene inhibitors suppress another path starting with arachidonic acid. They are primarily used fr he treatment of asthma, as leukotrienes are part of late-phase inflammatory reactions, even though cyclooxygenase inhibitors can aggravate asthna. In addition, they can also relieve pain.
References
- ↑ Anonymous (2024), Cyclooxygenase inhibitor (English). Medical Subject Headings. U.S. National Library of Medicine.