Cervical cancer: Difference between revisions
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===Papanicolaou smear=== | ===Papanicolaou smear=== | ||
A [[systematic review]] of available studies found the follow results.<ref name="pmid18165406">{{cite journal |author=Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch P, Siebers AG, Bulten J |title=Liquid Compared With Conventional Cervical Cytology: A Systematic Review and Meta-analysis |journal=Obstet Gynecol |volume=111 |issue=1 |pages=167–177 |year=2008 |pmid=18165406 |doi=10.1097/01.AOG.0000296488.85807.b3 |issn=}}</ref> | |||
{| class="wikitable" | |||
|+ Ability to detect ASCUS or worse.<ref name="pmid18165406"/> | |||
! !!colspan="2"| ASCUS or worse!!colspan="2"| High grade or worse | |||
|- | |||
| || [[sensitivity (tests)|sensitivity]]|| [[specificity (tests)|specificity]]|| [[sensitivity (tests)|sensitivity]]|| [[specificity (tests)|specificity]] | |||
|- | |||
| Conventional method || 88%|| 71%|| 55%|| 97% | |||
|- | |||
| Liquid-based thin prep || 88%|| 71%|| 57%|| 97% | |||
|} | |||
==== | A more recent study of the convention method reported very similar results:<ref name="pmid17942871">{{cite web |url=http://content.nejm.org/cgi/content/full/357/16/1579 |title=Human Papillomavirus DNA versus Papanicolaou Screening Tests for Cervical Cancer |accessdate=2007-10-18 |format= |work=}}</ref> | ||
* [[sensitivity (tests)|sensitivity]] 55% | |||
* [[specificity (tests)|specificity]] 94% | |||
===Human papillomavirus testing=== | ===Human papillomavirus testing=== | ||
Revision as of 15:40, 18 January 2008
Screening
In a randomized controlled trial, the addition of Human papillomavirus testing to screenng for cervical cancer "reduces the incidence of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected by subsequent screening examinations."[1]
Papanicolaou smear
A systematic review of available studies found the follow results.[2]
| ASCUS or worse | High grade or worse | |||
|---|---|---|---|---|
| sensitivity | specificity | sensitivity | specificity | |
| Conventional method | 88% | 71% | 55% | 97% |
| Liquid-based thin prep | 88% | 71% | 57% | 97% |
A more recent study of the convention method reported very similar results:[1]
- sensitivity 55%
- specificity 94%
Human papillomavirus testing
- sensitivity 95%[1]
- specificity 97%[1]
Combined testing
If either the Papanicolaou smear or Human papillomavirus testing are abnormal:
- sensitivity 100%[1]
- specificity 93%[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Human Papillomavirus and Papanicolaou Tests to Screen for Cervical Cancer. Retrieved on 2007-10-18. Cite error: Invalid
<ref>tag; name "pmid17942871" defined multiple times with different content - ↑ 2.0 2.1 Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch P, Siebers AG, Bulten J (2008). "Liquid Compared With Conventional Cervical Cytology: A Systematic Review and Meta-analysis". Obstet Gynecol 111 (1): 167–177. DOI:10.1097/01.AOG.0000296488.85807.b3. PMID 18165406. Research Blogging.