Caffeine

From Citizendium
Revision as of 11:40, 10 October 2008 by imported>Robert Badgett
Jump to navigation Jump to search
This article is a stub and thus not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.

Caffeine, contained in coffee and other drinks, is a mild stimulant and "is the most widely used psychoactive drug in the world."[1]

Cessation of caffeine intake can lead to withdrawal symptoms.[2]

Pharmacology

Caffeine competitively antagonizes adenosine receptors. This antagonism prevents adenosine's inhibition of intracellular cyclic AMP. Cyclic AMP is a second messenger that increases sympathetic stimulation and increases norepinephrine and dopamine release[1]

References

  1. 1.0 1.1 O'Brien, Charles (2006). “Chapter 23. Drug Addition and Drug Abuse”, Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th. New York: McGraw-Hill. ISBN 0-07-142280-3. 
  2. Silverman K, Evans SM, Strain EC, Griffiths RR (October 1992). "Withdrawal syndrome after the double-blind cessation of caffeine consumption". The New England journal of medicine 327 (16): 1109–14. PMID 1528206[e]