Atorvastatin: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
(drug interactions)
imported>Caesar Schinas
m (Bot: Update image code)
 
(9 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{subpages}}
{{subpages}}
[[Image:Atorvastatin structure.jpg|right|thumb|200px|{{#ifexist:Template:Atorvastatin structure.jpg/credit|{{Atorvastatin structure.jpg/credit}}<br/>|}}Atorvastatin, a class II statin.]]
{{Image|Atorvastatin structure.jpg|right|200px|Atorvastatin, a type II statin.}}


'''Atorvastatin''', commonly called '''Lipitor''', is a class II statin used to treat high cholesterol ([[hypercholesterolemia]]), prevent [[mycardial infarction|heart attacks]] and [[stroke]]s, and to lessen the formation of [[atherlosclerosis|artial plaque]].  It is a [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]] that decreases the synthesis of [[mevalonate]], a key chemical precursor of [[cholesterol]].  Although the structure is based on an indole ring, as are the other class II statins [[fluvastatin]] and [[rosuvastatin]], its longer half-life and specificity for the liver makes atorvastatin a better drug for lowering LDL-cholesterol levels. The metabolites of atorvastatin, ortho- and parahydroxylated derivatives and various beta-oxidation products, are equivalent HMG-CoA reductase inhibitors.  The drug should be taken with a low fat meal and alcohol and grapefruit juice should be avoided.  Atorvastatin can be toxic, leading to liver problems, rhabdomyolysis and eye hemorrhages.  
'''Atorvastatin''', commonly called '''Lipitor'''®, is a type II statin used to treat high cholesterol ([[hypercholesterolemia]]), prevent [[myocardial infarction|heart attacks]] and [[stroke]]s, and to lessen the formation of [[atherosclerosis|artial plaque]].  It is a [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]] that decreases the synthesis of [[mevalonate]], a key chemical precursor of [[cholesterol]].  Although the structure is based on an indole ring, as are the other type II statins [[fluvastatin]] and [[rosuvastatin]], its longer half-life and specificity for the liver makes atorvastatin a better drug for lowering LDL-cholesterol levels. The metabolites of atorvastatin, ortho- and parahydroxylated derivatives and various beta-oxidation products, are equivalent HMG-CoA reductase inhibitors.  The drug should be taken with a low fat meal and alcohol and grapefruit juice should be avoided.  Atorvastatin can be toxic, leading to liver problems, [[rhabdomyolysis]] and eye hemorrhages.  


Its official IUPAC chemical name is (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid and it has chemical formula C<sub>33</sub>H<sub>35</sub>FN<sub>2</sub>O<sub>5</sub>.
Its official IUPAC chemical name is (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid and it has chemical formula C<sub>33</sub>H<sub>35</sub>FN<sub>2</sub>O<sub>5</sub>.
== Drug interactions ==
The effects and/or toxicity of atorvastatin may be increased when taken in combination with [[amprenavir]], [[ataxanavir]], [[clarithromycin]], [[diltiazem]], [[erythromycin]], the NNRT inhibitors [[delavirdine]], [[eavirenz]] and [[nevirapine]], [[fosamprenavir]], [[imatinib]], [[indinavir]], [[josamycin]], [[nefazodone]], [[nelfinavir]], [[quinupristin]], [[ritonavir]], [[saquinavir]], [[tacrolimus]], [[telithromycin]] and  [[verapamil]].  The effects of atorvastatin may decrease when used in combination with [[bosentan]], [[carbamazepine]], [[rifabutin]] and [[rifampin]].  The risks of [[myopathy]] and/or  [[rhabdomyolysis]] increase when atorvastatin is used with [[bezafibrate]], [[colchicine]], [[cyclosporine]], [[fenofibrate]], [[fluconazole]], [[gemfibrozil]], [[itraconazole]] and  [[ketoconazole]].


== brand names ==
== brand names ==
*Cardyl
*Cardyl®
*Lipitor
*Lipitor®
*Sotis
*Sotis®
*Torvast
*Torvast®
*Tozalip
*Tozalip®
*Xavator
*Xavator®
*Sortis
*Sortis®
*Torvacard
*Torvacard®
*Totalip
*Totalip®
*Tulip
*Tulip®
*Xarator
*Xarator®
*Atorpic
*Atorpic®
*Liprimar
*Liprimar®
 


== Drug interactions ==


* [[Amprenavir]] can possibly increase the statin
==External links==
* [[Atazanavir]] increases the effect and toxicity of the statin
{{CZMed}}
* [[Bezafibrate]] increases the risk of [[myopathy]]/[[rhabdomyolysis]]
* [[Bosentan]] could decrease atorvastatin
* [[Carbamazepine]] decreases the effect of the statin
* [[Colchicine]] increases the risk of rhadbomyolysis with this combination
* [[Clarithromycin]] possibly increases the statin toxicity
* [[Cyclosporine]] may cause [[myopathy]] and [[rhabdomyolysis]]
* [[Delavirdine]] an [[NNRT inhibitor]] increases the effect and toxicity of the statin
* [[Diltiazem]] increases the effect and toxicity of atorvastatin
* [[Efavirenz]], an NNRT inhibitor, increases the effect and toxicity of the statin
* [[Erythromycin]] possibly increases the statin toxicity
* [[Fenofibrate]] Increasing risk of myopathy/rhabdomyolysis
* [[Fluconazole]] Increases the risk of myopathy/rhabdomyolysis
* [[Fosamprenavir]] Amprenavir can possibly increase the statin toxicity
* [[Gemfibrozil]] Increases the risk of myopathy/rhabdomyolysis
* [[Imatinib]] increases the effect and toxicity of atorvastatin
* [[Indinavir]] increases the effect and toxicity of atorvastatin
* [[Itraconazole]] Increases the risk of myopathy/rhabdomyolysis
* [[Josamycin]], a macrolide, possibly increases the statin toxicity
* [[Ketoconazole]] increases the risk of myopathy/rhabdomyolysis
* [[Nefazodone]] increases the effect and toxicity of the statin drug
* [[Nelfinavir]] increases the effect and toxicity of the statin
* [[Nevirapine]], an NNRT inhibitor, increases the effect and toxicity of the statin
* [[Quinupristin]] presents an increased risk of toxicity
* [[Rifabutin]], a [[rifamycin]], decreases the effect of the statin drug
* [[Rifampin]], a rifamycin, decreases the effect of the statin drug
* [[Ritonavir]] increases the effect and toxicity of the statin
* [[Saquinavir]] increases the effect and toxicity of atorvastatin
* [[Tacrolimus]] increases the effect and toxicity of the statin
* [[Telithromycin]] may possibly increase statin toxicity
* [[Verapamil]] increases the effect and toxicity of the statin

Latest revision as of 06:18, 8 June 2009

This article is a stub and thus not approved.
 Main Article
 Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
https://en.citizendium.org/wiki/index.php?title=Atorvastatin&printable=yes
This editable Main Article is under development and subject to a disclaimer.
(CC) Image: David E. Volk
Atorvastatin, a type II statin.

Atorvastatin, commonly called Lipitor®, is a type II statin used to treat high cholesterol (hypercholesterolemia), prevent heart attacks and strokes, and to lessen the formation of artial plaque. It is a HMG-CoA reductase inhibitor that decreases the synthesis of mevalonate, a key chemical precursor of cholesterol. Although the structure is based on an indole ring, as are the other type II statins fluvastatin and rosuvastatin, its longer half-life and specificity for the liver makes atorvastatin a better drug for lowering LDL-cholesterol levels. The metabolites of atorvastatin, ortho- and parahydroxylated derivatives and various beta-oxidation products, are equivalent HMG-CoA reductase inhibitors. The drug should be taken with a low fat meal and alcohol and grapefruit juice should be avoided. Atorvastatin can be toxic, leading to liver problems, rhabdomyolysis and eye hemorrhages.

Its official IUPAC chemical name is (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid and it has chemical formula C33H35FN2O5.

Drug interactions

The effects and/or toxicity of atorvastatin may be increased when taken in combination with amprenavir, ataxanavir, clarithromycin, diltiazem, erythromycin, the NNRT inhibitors delavirdine, eavirenz and nevirapine, fosamprenavir, imatinib, indinavir, josamycin, nefazodone, nelfinavir, quinupristin, ritonavir, saquinavir, tacrolimus, telithromycin and verapamil. The effects of atorvastatin may decrease when used in combination with bosentan, carbamazepine, rifabutin and rifampin. The risks of myopathy and/or rhabdomyolysis increase when atorvastatin is used with bezafibrate, colchicine, cyclosporine, fenofibrate, fluconazole, gemfibrozil, itraconazole and ketoconazole.

brand names

  • Cardyl®
  • Lipitor®
  • Sotis®
  • Torvast®
  • Tozalip®
  • Xavator®
  • Sortis®
  • Torvacard®
  • Totalip®
  • Tulip®
  • Xarator®
  • Atorpic®
  • Liprimar®


External links

The most up-to-date information about Atorvastatin and other drugs can be found at the following sites.

Retrieved from "https://citizendium.org/wiki/index.php?title=Atorvastatin&oldid=392986"