Alpha-fetoproteins: Difference between revisions
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imported>Howard C. Berkowitz (New page: '''Alpha-fetoproteins (AFP, α-fetoproteins)''' are the first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embr...) |
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'''Alpha-fetoproteins (AFP, α-fetoproteins)''' are the first alpha-[[globulin]]s to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. Their level drops after birth, but may be elevated in certain diseases. | '''Alpha-fetoproteins (AFP, α-fetoproteins)''' are the first alpha-[[globulin]]s to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. Their level drops after birth, but may be elevated in certain diseases. | ||
==Use in Obstetrics== | ==Use in Obstetrics== | ||
They may also be elevated in the amniotic fluid and maternal serum during pregnancy in [[anencephaly]] | They may also be elevated in the amniotic fluid and maternal serum during pregnancy in [[anencephaly]] | ||
One determination procedure uses [[radioimmunoassay]] of infant heel-stick blood. <ref name=>{{citation | One determination procedure uses [[radioimmunoassay]] of infant heel-stick blood. <ref name=Mlzejewski >{{citation | ||
| journal = Pediatr Res. | | journal = Pediatr Res. | ||
| volume = 17 | | volume = 17 | ||
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| title =Measurement of serum alpha-fetoprotein in early infancy: utilization of dried blood specimens. | | title =Measurement of serum alpha-fetoprotein in early infancy: utilization of dried blood specimens. | ||
| author = Mlzejewski GJ ''et al.'' | | author = Mlzejewski GJ ''et al.'' | ||
|url = http://www.ncbi.nlm.nih.gov/pubmed/6188092}</ref> The authors see AFP as a screening test requiring followup determination for other genetic disorders. | |url = http://www.ncbi.nlm.nih.gov/pubmed/6188092}}</ref> The authors see AFP as a screening test requiring followup determination for other genetic disorders. | ||
Their use as a fetal diagnostic is declining.<ref name=>{{citation | |||
| title = Routine assessment of amniotic fluid alpha-Fetoprotein in early second-trimester | |||
| author = Kjerstin FW, Gottvall T | |||
| journal = Acta obstetricia et gynecologica Scandinavica | |||
|ISSN=0001-6349 | |||
| year = 2007 | |||
| volume = 86 | issue = 2 | pages = 167-171 | |||
|url = http://cat.inist.fr/?aModele=afficheN&cpsidt=18531111}}</ref> | |||
==Use in Oncology and Gastroenterology== | ==Use in Oncology and Gastroenterology== | ||
They reappear in the adult [[serum (human)|serum]] during certain pathologic states, | They reappear in the adult [[serum (human)|serum]] during certain pathologic states, such as [[hepatocellular carcinoma|primary hepatocellular carcinoma]] and [[hepatolenticular degeneration]] ([[Wilson's disease]]). <ref name=Covin>{{citation | ||
| title = Liver and Gallbladder Pathology | |||
| author = Covin, RB | |||
| publisher = University of Medicine and Dentistry of New Jersey | |||
| date = April 4, 2006 | |||
| url = http://www2.umdnj.edu/pathpweb/Lectures/Liver%20and%20GB%20Pathology%20-%20Covin%202006.pdf}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 13:30, 25 January 2009
Alpha-fetoproteins (AFP, α-fetoproteins) are the first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. Their level drops after birth, but may be elevated in certain diseases.
Use in Obstetrics
They may also be elevated in the amniotic fluid and maternal serum during pregnancy in anencephaly One determination procedure uses radioimmunoassay of infant heel-stick blood. [1] The authors see AFP as a screening test requiring followup determination for other genetic disorders.
Their use as a fetal diagnostic is declining.[2]
Use in Oncology and Gastroenterology
They reappear in the adult serum during certain pathologic states, such as primary hepatocellular carcinoma and hepatolenticular degeneration (Wilson's disease). [3]
References
- ↑ Mlzejewski GJ et al. (January 1983), "Measurement of serum alpha-fetoprotein in early infancy: utilization of dried blood specimens.", Pediatr Res. 17 (1): 47-50
- ↑ Kjerstin FW, Gottvall T (2007), "Routine assessment of amniotic fluid alpha-Fetoprotein in early second-trimester", Acta obstetricia et gynecologica Scandinavica 86 (2): 167-171, ISSN 0001-6349
- ↑ Covin, RB (April 4, 2006), Liver and Gallbladder Pathology, University of Medicine and Dentistry of New Jersey