Aldosterone
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Aldosterone, also called (11ß)-11,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al, is a steroid hormone. It is the major mineralcorticoid and it therefore controls electrolyte levels, blood pressure and hydration. Aldosterone is synthesized from corticosterone by oxidation of the C-18 methyl group to form an aldehyde.
Primary aldosteronism
Primary aldosteronism underlies about 10% of cases of resistant hypertension.[1]
Clinical practice guidelines are available for managing primary aldosteronism.[2] A aldosterone renin ratio (ARR) over 20 with an elevated aldosterone level suggests primary hyperaldosteronism.[2]
References
- ↑ Douma S, Petidis K, Doumas M, et al (June 2008). "Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study". Lancet 371 (9628): 1921–6. DOI:10.1016/S0140-6736(08)60834-X. PMID 18539224. Research Blogging.
- ↑ 2.0 2.1 Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M et al. (2008). "Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline.". J Clin Endocrinol Metab 93 (9): 3266-81. DOI:10.1210/jc.2008-0104. PMID 18552288. Research Blogging. Free fulltext