3-hydroxy-3-methyl-glutaryl CoA: Difference between revisions
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{{Image|Mevalonate synthesis.jpg|right|250px|Biosynthesis of mevalonate from HMG CoA.}} | |||
The biochemical '''3-hydroxy-3-methyl-glutaryl CoA''' '''(HMG CoA)''', is a chemical precursor of [[mevalonate]], which is a key metabolite in the synthesis of [[cholesterol]]. The cholesterol-lowering statins, such as [[Lipitor]] and [[Crestor]], among others, are [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]]s which block the synthesis of mevalonate from HMG CoA. | The biochemical '''3-hydroxy-3-methyl-glutaryl CoA''' '''(HMG CoA)''', is a chemical precursor of [[mevalonate]], which is a key metabolite in the synthesis of [[cholesterol]]. The cholesterol-lowering statins, such as [[Lipitor]] and [[Crestor]], among others, are [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]]s which block the synthesis of mevalonate from HMG CoA. | ||
Latest revision as of 06:05, 8 June 2009
The biochemical 3-hydroxy-3-methyl-glutaryl CoA (HMG CoA), is a chemical precursor of mevalonate, which is a key metabolite in the synthesis of cholesterol. The cholesterol-lowering statins, such as Lipitor and Crestor, among others, are HMG-CoA reductase inhibitors which block the synthesis of mevalonate from HMG CoA.