Molluscum contagiosum

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Molluscum Contagiosum Virus
[[image: Molluscum Contagiosum Virus. |200px|]]
Scientific classification
Kingdom: Virus Family: Poxviridae Genus: Molluscipoxvirus Species: Molluscum contagiosum virus

Introduction

Molluscum Contagiosum Virus was first described and later it was named by Bateman in the early nineteenth century. Over time, there was more cases that were described and similar to this virus, and overtime there was more and more information gathered on this. Goodpasture later described the similarities of molluscum and vaccinia. Molluscum Contagiosum Virus is a poxvirus, which is a member of the family Poxviridae. Poxvirus are viruses that can be a family that infect both vertebrate and invertebrate animals. Molluscum contagiosum is a viral infection that seems to cause lots of papules or nodules on the skin. This disease it thought to infect humans only, but there has been cases where they found animals with Molluscum Contagiosum. This virus is said to be most common in children, but is found in sexually active adults, and those that are not immuned. It is found worldwide with an increase in tropical areas. This disease is more prominent in areas, populations, institutions and communities with overcrowding, very bad hygiene, and high rate of poverty.

Description and Significance

There are various types of Molluscum Contagiosum Virus, and they are most commonly seen on humans, but have been found to be on animals such as chickens, horses, oxes, cows, etc. On humans, they are seen on children and sexually active adults. This virus is very contagious that can spread by contact of infected individuals or by association with fomites. Fomites being infected clothes, toys, towels, etc.

It is found that there has been an increase of this disease mainly as a sexually transmitted disease, and seen that it is particularly rampant as a result of HIV (human immunodeficiency virus) infection. It is estimated to be between 5% to 20% of patients with HIV have symptoms of MCV.

Taxonomy

To explain this further, Molluscum Contagiousum is a poxviruses from the family of Poxviridae. There are four genera, which are Orthopox, Parapox, Yatapox, and Molluscipox. Molluscipox gives rise to the virus Molluxcum Contagiosum. The name for Poxviridae viruses comes from the original grouping of the virus related with the disease that produced poxes on the skin. The subfamily is Chordopoxvirinae, with the Genus Molluscipoxvirus, and the species being MCV. Types of Viruses for each genera: Orthopox: variola virus, vaccinia virus, cowpox virus, monkeypox virus, smallpox ; Parapox: orf virus, pseudocowpox, bovine papular stomatitis virus; Yatapox: tanapox virus, yaba monkey tumor virus; Molluscipox: molluscum contagiosum virus (MCV). There are four main subtypes of molluscum contagiosum: MCV I, MCV II, MCV III, and MCV IV.[15,16] All subtypes cause similar clinical lesions in genital and nongenital regions. Studies show MCV I to be more prevalent (75%–90%) than MCV II, MCV III, and MCV IV, except in immunocompromised individuals.

Genome Structure

Genome_MCV

. By the colaboration of information from experiments conducted over the years by Tatiana G. Senkevicha, Eugene V. Kooninb, Joachim J. Bugertc, a, Gholamreza Daraic and Bernard Mossa, we discovered that the Molluscum Contagiosum Virus is a non-segmented molecule of double-stranded linear DNA with 180,000 to 200,000 nucleotides.It is said that there are 160 genes identified which encode 182 proteins. Among those, 105 proteins are counterparts in OPV (''Orthopoxviruses''). The OPV protein are considered to be the essential proteins for replication, and is noted that these proteins are highly conserved in MCV when undergoing transcription. There are twenty MCV proteins with OPV counterparts that have their own homologs, and some even have their own functional motifs. Despite other factors, the physical order and regulation of essential ancestral poxvirus genes have been largely conserved in these MCV's and OPV's. The picture on the right is a table of Genomic information on various viruses.