3-hydroxy-3-methyl-glutaryl CoA

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Revision as of 13:27, 24 January 2008 by imported>David E. Volk (New page: {{subpages}} [[Image:Mevalonate synthesis.jpg|right|thumb|250px|{{#ifexist:Template:Mevalonate synthesis.jpg/credit|{{Mevalonate synthesis.jpg/credit}}<br/>|}}Biosynthesis of mevalonate fr...)
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Biosynthesis of mevalonate from HMG CoA.

The biochemical 3-hydroxy-3-methyl-glutaryl CoA, often abbreviated as HMG CoA, is a chemical precursor of mevalonate, which is a key metabolite in the synthesis of cholesterol. The cholesterol-lowering statins, such as Lipitor and Crestor, among others, are HMG-CoA reductase inhibitor which block the synthesis of mevalonate from HMG CoA.

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