Platelet glycoprotein GPIIb-IIIa complex

Platelet Glycoprotein GPIIb-IIIa Complex is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."

Role in medicine

A deficiency of GPIIb-IIIa is the cause of Glanzman Thrombasthenia, which causes a prolonged bleeding time.

Antibodies to GPIIb-IIIa is the cause of most cases of chronic idiopathic thrombocytopenic purpura (ITP).

Glycoprotein IIb/IIIa inhibitors are platelet aggregation inhibitors used to treat cardiovascular diseases.

External links

• MeSH
• Entrez Gene
  • Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
• OMIM Gene map