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{{r|Aldosterone receptor}}

The angiotensins also cause release of [[aldosterone]] from the [[adrenal cortex]] and are powerful [[dipsogen]] as a result of ...-Phe'') has 40% of the pressor activity of angiotensin II, but 100% of the aldosterone-producing activity.

{{Image|Spironolactone DEVolk.jpg|right|150px|Spironolactone, an aldosterone antagonist.}} '''Spironolactone''' is an [[aldosterone antagonist]] used to treat [[edema]] associated with congestive [[heart fai

...ions. It interacts with the [[Renin-angiotensin system | renin-angiotensin-aldosterone system]] to regulate [[blood pressure]], generation of [[prostaglandin]]s,

...e a major bearing on the normal function of the [[endocrine system]] are [[aldosterone]] (the major mineralocorticoid), and [[cortisol]] (the main glucocorticoid)

...od pressure]]. In addition, [[angiotensin]] II stimulates the release of [[aldosterone]] from the adrenal cortex, which in turn also increases salt and water rete ===Aldosterone antagonists===

...ffects mediated by the AT₁ receptor include vasoconstriction, [[aldosterone]] synthesis and secretion, increased [[vasopressin]] secretion, cardiac [[h

{{r|Aldosterone}}

** Consider adding an ARB, but the guideline lists the option of adding an aldosterone antagonist first ...espite optimal treatment with an ACEI and β-blocker, unless also taking an aldosterone antagonist."

{{r|Aldosterone}}

...e natriuresis; diuresis; vasodilation; and inhibits secretion of renin and aldosterone. It improves heart function. It contains 32 amino acids."<ref>{{MeSH}}</ref ...Natriuretic peptides are functional antagonists to the [[renin-angiotensin-aldosterone system]]. BNP was given its name because it was first discovered in the por

...450px|Structures of cortisol, the major glucocorticoid, corticosterone and aldosterone, the major mineralcorticoid.}} ...ation at C-21 to synthesize cortisol, otherwise corticosterone is formed. Aldosterone, the major mineralcorticoid, is synthesized from corticosterone by oxidatio

====Aldosterone antagonists==== ...ournal| author=Navaneethan SD, Nigwekar SU, Sehgal AR, Strippoli GF| title=Aldosterone antagonists for preventing the progression of chronic kidney disease. | jou

...stal-tubule diuretics such as [[triamterene]] or [[amiloride]]) block the aldosterone receptor in the collecting tubule. Their benefit was shown in a [[randomize

...e]], the [[glucocorticoid]]s [[budesonide]] and [[ciclesonide]] and the [[aldosterone]] agonist [[eplerenone]]. It also increase the effects of some [[antiviral

...e]], the [[glucocorticoid]]s [[budesonide]] and [[ciclesonide]] and the [[aldosterone]] agonist [[eplerenone]]. It also increase the effects of some [[antiviral

...osterone]] and plasma [[renin]] activity ratio of more than 65:16 with a [[aldosterone]] concentration above 416 pmol/L. However, only 10% of all patients had pri ...Brunner HR, Buhler FR, Sealey JE, Vaughan ED| title=Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. | j

...me="pmid19066207">{{cite journal| author=Ezekowitz JA, McAlister FA| title=Aldosterone blockade and left ventricular dysfunction: a systematic review of randomize ** Consider adding an ARB, but the guideline lists the option of adding an aldosterone antagonist first

* plasma aldosterone concentration and plasma renin activity ''if hypertension is present''

...blood pressure-independent protection by blockade of the renin angiotensin aldosterone system? | journal=Hypertension | year= 2003 | volume= 41 | issue= 2 | pages