Thrombotic thrombocytopenic purpura
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In medicine and hematology, thrombotic thrombocytopenic purpura (TTP) is "an acquired, congenital, or familial disorder caused by platelet aggregation with thrombosis in terminal arterioles and capillaries. Clinical features include thrombocytopenia; hemolytic anemia; azotemia; fever; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as renal failure."[1]
Patients with primary TTP may have low von Willebrand factor-degrading protease (ADAMTS13 protein) which allows thrombi due to von Willebrand factor (vWF).[2]
References
- ↑ Anonymous (2025), Thrombotic thrombocytopenic purpura (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Hovinga JA, Vesely SK, Terrell DR, Lämmle B, George JN (2010). "Survival and relapse in patients with thrombotic thrombocytopenic purpura.". Blood 115 (8): 1500-11; quiz 1662. DOI:10.1182/blood-2009-09-243790. PMID 20032506. Research Blogging.