Subclinical hypothyroidism: Difference between revisions

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"In current RCTs, levothyroxine  replacement therapy for subclinical hypothyroidism did not result in  improved survival or decreased cardiovascular morbidity" according to a [[meta-analysis]] by the [[Cochrane Collaboration]]. <ref  name="pmid17636722">{{cite journal| author=Villar HC, Saconato H,  Valente O, Atallah AN| title=Thyroid hormone replacement for subclinical  hypothyroidism. | journal=Cochrane Database Syst Rev | year= 2007 |  volume=  | issue= 3 | pages= CD003419 | pmid=17636722 |  doi=10.1002/14651858.CD003419.pub2 | pmc= | url= }}  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18170994  Review in: ACP J Club. 2008 Jan-Feb;148(1):7]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18170993  Review in: ACP J Club. 2008 Jan-Feb;148(1):6]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18234930  Review in: Evid Based Med. 2008 Feb;13(1):22] </ref> Subsequent [[randomized controlled trial]]s have been positive using 100 microg T4 orally per day<ref name="pmid17299073">{{cite journal| author=Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU| title=The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. | journal=J Clin Endocrinol Metab | year= 2007 | volume= 92 | issue= 5 | pages= 1715-23 | pmid=17299073 | doi=10.1210/jc.2006-1869 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17299073  }} </ref> and negative using 25 microg T4 orally per day<ref name="pmid20501682">{{cite journal| author=Parle J, Roberts L, Wilson S, Pattison H, Roalfe A, Haque MS et al.| title=A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study. | journal=J Clin Endocrinol Metab | year= 2010 | volume= 95 | issue= 8 | pages= 3623-32 | pmid=20501682 | doi=10.1210/jc.2009-2571 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20501682  }} </ref>.
"In current RCTs, levothyroxine  replacement therapy for subclinical hypothyroidism did not result in  improved survival or decreased cardiovascular morbidity" according to a [[meta-analysis]] by the [[Cochrane Collaboration]]. <ref  name="pmid17636722">{{cite journal| author=Villar HC, Saconato H,  Valente O, Atallah AN| title=Thyroid hormone replacement for subclinical  hypothyroidism. | journal=Cochrane Database Syst Rev | year= 2007 |  volume=  | issue= 3 | pages= CD003419 | pmid=17636722 |  doi=10.1002/14651858.CD003419.pub2 | pmc= | url= }}  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18170994  Review in: ACP J Club. 2008 Jan-Feb;148(1):7]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18170993  Review in: ACP J Club. 2008 Jan-Feb;148(1):6]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18234930  Review in: Evid Based Med. 2008 Feb;13(1):22] </ref> Subsequent [[randomized controlled trial]]s have been positive using 100 microg T4 orally per day<ref name="pmid17299073">{{cite journal| author=Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU| title=The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. | journal=J Clin Endocrinol Metab | year= 2007 | volume= 92 | issue= 5 | pages= 1715-23 | pmid=17299073 | doi=10.1210/jc.2006-1869 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17299073  }} </ref> and negative using 25 microg T4 orally per day<ref name="pmid20501682">{{cite journal| author=Parle J, Roberts L, Wilson S, Pattison H, Roalfe A, Haque MS et al.| title=A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study. | journal=J Clin Endocrinol Metab | year= 2010 | volume= 95 | issue= 8 | pages= 3623-32 | pmid=20501682 | doi=10.1210/jc.2009-2571 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20501682  }} </ref>.


[[Clinical practice guideline]]s guide management.
[[Clinical practice guideline]]s guide management.<ref name="pmid22967432">{{cite journal| author=Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI et al.| title=Clinical Practice Guidelines for Hypothyroidism in Adults: Co-sponsored by American Association of Clinical Endocrinologists and the American Thyroid Association. | journal=Endocr Pract | year= 2012 | volume=  | issue=  | pages= 1-207 | pmid=22967432 | doi=10.4158/EP12280.GL | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22967432  }} </ref>


Prior consensus statements conflict with some recommending<ref name="pmid15687817">{{cite journal| author=Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT et al.| title=Consensus Statement #1: Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. | journal=Thyroid | year= 2005 | volume= 15 | issue= 1 | pages= 24-8; response 32-3 | pmid=15687817 | doi=10.1089/thy.2005.15.24 | pmc= | url= }} </ref><ref name="pmid16033723">{{cite journal| author=Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT et al.| title=Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. | journal=Endocr Pract | year= 2004 | volume= 10 | issue= 6 | pages= 497-501 | pmid=16033723 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16033723  }} </ref><ref name="pmid15643019">{{cite journal| author=Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT| title=Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. | journal=J Clin Endocrinol Metab | year= 2005 | volume= 90 | issue= 1 | pages= 581-5; discussion 586-7 | pmid=15643019 | doi=10.1210/jc.2004-1231 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15643019  }} </ref> and others not<ref name="pmid14722150">{{cite journal| author=Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH et al.| title=Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. | journal=JAMA | year= 2004 | volume= 291 | issue= 2 | pages= 228-38 | pmid=14722150 | doi=10.1001/jama.291.2.228 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14722150  }} </ref> recommending treatment.<ref name="pmid15643021">{{cite journal| author=Ringel MD, Mazzaferri EL| title=Subclinical thyroid dysfunction--can there be a consensus about the consensus? | journal=J Clin Endocrinol Metab | year= 2005 | volume= 90 | issue= 1 | pages= 588-90 | pmid=15643021 | doi=10.1210/jc.2004-2173 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15643021  }} </ref>
Prior consensus statements conflict with some recommending<ref name="pmid15687817">{{cite journal| author=Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT et al.| title=Consensus Statement #1: Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. | journal=Thyroid | year= 2005 | volume= 15 | issue= 1 | pages= 24-8; response 32-3 | pmid=15687817 | doi=10.1089/thy.2005.15.24 | pmc= | url= }} </ref><ref name="pmid16033723">{{cite journal| author=Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT et al.| title=Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. | journal=Endocr Pract | year= 2004 | volume= 10 | issue= 6 | pages= 497-501 | pmid=16033723 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16033723  }} </ref><ref name="pmid15643019">{{cite journal| author=Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT| title=Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. | journal=J Clin Endocrinol Metab | year= 2005 | volume= 90 | issue= 1 | pages= 581-5; discussion 586-7 | pmid=15643019 | doi=10.1210/jc.2004-1231 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15643019  }} </ref> and others not<ref name="pmid14722150">{{cite journal| author=Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH et al.| title=Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. | journal=JAMA | year= 2004 | volume= 291 | issue= 2 | pages= 228-38 | pmid=14722150 | doi=10.1001/jama.291.2.228 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14722150  }} </ref> recommending treatment.<ref name="pmid15643021">{{cite journal| author=Ringel MD, Mazzaferri EL| title=Subclinical thyroid dysfunction--can there be a consensus about the consensus? | journal=J Clin Endocrinol Metab | year= 2005 | volume= 90 | issue= 1 | pages= 588-90 | pmid=15643021 | doi=10.1210/jc.2004-2173 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15643021  }} </ref>

Revision as of 11:04, 5 December 2012

In medicine, subclinical hypothyroidism is an elevated thyrotropin (TSH) concentration can maintain a normal or near normal thyroxine (T4) concentration.[1][2]

Prognosis

"Subclinical hypothyroidism is associated with an increased risk of CHD events and CHD mortality in those with higher TSH levels, particularly in those with a TSH concentration of 10 mIU/L or greater" according to a individual patient data meta-analysis. [3]

Thyrotropin level

Evolution of thyrotropin values over 5 years.[4]
  Follow-up TSH value
TSH > 10 TSH < 10
TSH > 10 35% 64%
TSH 5.5 - 10 3% 97%

The thyrotropin level helps predict progression to overt hypothyroidism.[4]

Antithyroid peroxidase antibodies

Antithyroid peroxidase (also called antithyroid microsomal) antibodies my help predict progression to overt hypothyroidism.[5][6][7]

Diagnostic accuracy for predicting over hypothyroidism has been reported.

Diez et al found that among patients with TSH > 5, antibodies > 20 U/ml were significant predictors of hypothyrodism after 3.5 years of follow-up in which 26% developed overt hypothyroidism, but not after controlling for initial thyrotropin level.[7]

  • Sensitivity 93%
  • Specificity 30%
  • Positive predictive value 32%
  • Negative predictive value 92%

Walsh et al found that among patients with TSH> 4, antibodies > 35 U/ml were significant predictors of hypothyrodism after 13 years of follow-up in which 31% developed overt hypothyroidism, but not after controlling for initial thyrotropin level.[5]

  • Sensitivity 84%
  • Specificity 30%
  • Positive predictive value 60%
  • Negative predictive value 60%

Treatment

"In current RCTs, levothyroxine replacement therapy for subclinical hypothyroidism did not result in improved survival or decreased cardiovascular morbidity" according to a meta-analysis by the Cochrane Collaboration. [8] Subsequent randomized controlled trials have been positive using 100 microg T4 orally per day[9] and negative using 25 microg T4 orally per day[10].

Clinical practice guidelines guide management.[11]

Prior consensus statements conflict with some recommending[12][13][14] and others not[1] recommending treatment.[15]

Screening

The US Preventive Services Task Force states:[16]

"t is uncertain whether treatment will improve quality of life in otherwise healthy patients who have abnormal TSH levels and normal free thyroxine levels."

The Institute of Medicine recommends against screening.[17]

References

  1. ↑ 1.0 1.1 Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH et al. (2004). "Subclinical thyroid disease: scientific review and guidelines for diagnosis and management.". JAMA 291 (2): 228-38. DOI:10.1001/jama.291.2.228. PMID 14722150. Research Blogging.
  2. ↑ Cooper DS, Biondi B (2012). "Subclinical thyroid disease.". Lancet 379 (9821): 1142-54. DOI:10.1016/S0140-6736(11)60276-6. PMID 22273398. Research Blogging.
  3. ↑ Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP et al. (2010). "Subclinical hypothyroidism and the risk of coronary heart disease and mortality.". JAMA 304 (12): 1365-74. DOI:10.1001/jama.2010.1361. PMID 20858880. Research Blogging. Review in: Evid Based Med. 2011 Feb;16(1):31-2
  4. ↑ 4.0 4.1 Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI (2007). "Serum thyrotropin measurements in the community: five-year follow-up in a large network of primary care physicians.". Arch Intern Med 167 (14): 1533-8. DOI:10.1001/archinte.167.14.1533. PMID 17646608. Research Blogging. Cite error: Invalid <ref> tag; name "pmid17646608" defined multiple times with different content
  5. ↑ 5.0 5.1 Walsh JP, Bremner AP, Feddema P, Leedman PJ, Brown SJ, O'Leary P (2010). "Thyrotropin and thyroid antibodies as predictors of hypothyroidism: a 13-year, longitudinal study of a community-based cohort using current immunoassay techniques.". J Clin Endocrinol Metab 95 (3): 1095-104. DOI:10.1210/jc.2009-1977. PMID 20097710. Research Blogging. Cite error: Invalid <ref> tag; name "pmid20097710" defined multiple times with different content
  6. ↑ Li Y, Teng D, Shan Z, Teng X, Guan H, Yu X et al. (2008). "Antithyroperoxidase and antithyroglobulin antibodies in a five-year follow-up survey of populations with different iodine intakes.". J Clin Endocrinol Metab 93 (5): 1751-7. DOI:10.1210/jc.2007-2368. PMID 18270254. Research Blogging.
  7. ↑ 7.0 7.1 Díez JJ, Iglesias P (2004). "Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure.". J Clin Endocrinol Metab 89 (10): 4890-7. DOI:10.1210/jc.2003-032061. PMID 15472181. Research Blogging. Cite error: Invalid <ref> tag; name "pmid15472181" defined multiple times with different content
  8. ↑ Villar HC, Saconato H, Valente O, Atallah AN (2007). "Thyroid hormone replacement for subclinical hypothyroidism.". Cochrane Database Syst Rev (3): CD003419. DOI:10.1002/14651858.CD003419.pub2. PMID 17636722. Research Blogging. Review in: ACP J Club. 2008 Jan-Feb;148(1):7 Review in: ACP J Club. 2008 Jan-Feb;148(1):6 Review in: Evid Based Med. 2008 Feb;13(1):22
  9. ↑ Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU (2007). "The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial.". J Clin Endocrinol Metab 92 (5): 1715-23. DOI:10.1210/jc.2006-1869. PMID 17299073. Research Blogging.
  10. ↑ Parle J, Roberts L, Wilson S, Pattison H, Roalfe A, Haque MS et al. (2010). "A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study.". J Clin Endocrinol Metab 95 (8): 3623-32. DOI:10.1210/jc.2009-2571. PMID 20501682. Research Blogging.
  11. ↑ Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI et al. (2012). "Clinical Practice Guidelines for Hypothyroidism in Adults: Co-sponsored by American Association of Clinical Endocrinologists and the American Thyroid Association.". Endocr Pract: 1-207. DOI:10.4158/EP12280.GL. PMID 22967432. Research Blogging.
  12. ↑ Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT et al. (2005). "Consensus Statement #1: Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society.". Thyroid 15 (1): 24-8; response 32-3. DOI:10.1089/thy.2005.15.24. PMID 15687817. Research Blogging.
  13. ↑ Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT et al. (2004). "Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society.". Endocr Pract 10 (6): 497-501. PMID 16033723. [e]
  14. ↑ Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT (2005). "Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society.". J Clin Endocrinol Metab 90 (1): 581-5; discussion 586-7. DOI:10.1210/jc.2004-1231. PMID 15643019. Research Blogging.
  15. ↑ Ringel MD, Mazzaferri EL (2005). "Subclinical thyroid dysfunction--can there be a consensus about the consensus?". J Clin Endocrinol Metab 90 (1): 588-90. DOI:10.1210/jc.2004-2173. PMID 15643021. Research Blogging.
  16. ↑ Helfand M, U.S. Preventive Services Task Force (2004). "Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force.". Ann Intern Med 140 (2): 128-41. PMID 14734337. [e]
  17. ↑ Institute of Medicine (2003). Medicare Coverage of Routine Screening for Thyroid Dysfunction
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