Aminostatic hypothesis

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In 1956, Mellinkoff proposed the aminostatic hypothesis, stimulated by the observation that when normal individuals ingest protein, appetite diminishes as the serum amino acid concentration rises and vice versa.

References

Comparison of 2 diets with either 25% or 10% of energy as casein on energy expenditure, substrate balance, and appetite profile1–3 Ananda Hochstenbach-Waelen, Margriet AB Veldhorst, Arie G Nieuwenhuizen, Margriet S Westerterp-Plantenga, and Klaas R Westerterp

Influences of protein to energy ratios in breakfast on mood, alertness and attention in the healthy undergraduate students Yao-Chi Zeng1*, Shun-Min Li1, Guo-Liang Xiong1, Hui-Min Su2, Jian-Cheng Wan3