Saquinavir: Difference between revisions
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'''Saquinavir''', abbreviated '''SQV''' and sold under the trade names '''Fortovase®''', '''Invirase®''' and '''ROC®''', is a [[protease inhibitor]] used to treate [[HIV]]/[[AIDS]]. It is effective againsts HIV-1 and HIV-2. Saquinavir binds to the protease active site and inhibits its activity, thus preventing cleavage of the viral polyproteins resulting in immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs and due to their short half-life, often must be taken about every four hours. Its chemical name is (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide and its chemical formula is C<sub>38</sub>H<sub>5</sub>0N<sub>6</sub>O<sub>5</sub>. | {{Chem infobox | ||
|align=right | |||
|image=[[Image:Saquinavir structure.jpg|right|thumb|250px|{{#ifexist:Template:Saquinavir structure.jpg/credit|{{Saquinavir structure.jpg/credit}}<br/>|}}Saquinavir.]] | |||
|width=250px | |||
|molname=saquinavir | |||
|synonyms= SVQ | |||
|molformula= C<sub>38</sub>H<sub>5</sub>0N<sub>6</sub>O<sub>5</sub> | |||
|molmass= 670.8408 | |||
|uses=HIV | |||
|properties=protease inhibitor | |||
|hazards=see drug interactions | |||
|iupac= see Chemistry section | |||
|casnumber= 127779-20-8 | |||
}} | |||
'''Saquinavir''', abbreviated '''SQV''' and sold under the trade names '''Fortovase®''', '''Invirase®''' and '''ROC®''', is a [[protease inhibitor]] used to treate [[HIV]]/[[AIDS]]. It is effective againsts HIV-1 and HIV-2. Saquinavir binds to the protease active site and inhibits its activity, thus preventing cleavage of the viral polyproteins resulting in immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs and due to their short half-life, often must be taken about every four hours. | |||
== Chemistry == | |||
Its IUPAC chemical name is (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide and its chemical formula is C<sub>38</sub>H<sub>5</sub>0N<sub>6</sub>O<sub>5</sub>. | |||
== External links == | == External links == | ||
Revision as of 08:43, 22 March 2008
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| saquinavir | |||||||
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| Uses: | HIV | ||||||
| Properties: | protease inhibitor | ||||||
| Hazards: | see drug interactions | ||||||
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Saquinavir, abbreviated SQV and sold under the trade names Fortovase®, Invirase® and ROC®, is a protease inhibitor used to treate HIV/AIDS. It is effective againsts HIV-1 and HIV-2. Saquinavir binds to the protease active site and inhibits its activity, thus preventing cleavage of the viral polyproteins resulting in immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs and due to their short half-life, often must be taken about every four hours.
Chemistry
Its IUPAC chemical name is (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide and its chemical formula is C38H50N6O5.
External links
- Saquinavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Template:MedMaster
- Template:DrugBank