Simvastatin: Difference between revisions
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[[Image:Simvastatin structure.jpg|right|thumb| | [[Image:Simvastatin structure.jpg|right|thumb|250px|Simvastatin, a class I statin.]] | ||
'''Simvastatin''' is a methylated derivative of [[lovastatin]] used treat [[hypercholesterolemia]], to prevent [[myocardial infarction|heart attacks]] and strokes, and to diminish [[athlerosclorosis]]. It is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B. It inhibits the function of hydroxymethylglutaryl COA reductases, key enzymes in the production of [[cholesterol]]. It also increases LDL catabolism and may interfere with [[steroid]] production. It is structurally and functionally similar to the other class I [[statin]]s [[mevastatin]], [[lovastatin]] and [[pravastatin]]. Both the drug and its <math>\beta</math>-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins. | '''Simvastatin''' is a methylated derivative of [[lovastatin]] used treat [[hypercholesterolemia]], to prevent [[myocardial infarction|heart attacks]] and strokes, and to diminish [[athlerosclorosis]]. It is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B. It inhibits the function of hydroxymethylglutaryl COA reductases, key enzymes in the production of [[cholesterol]]. It also increases LDL catabolism and may interfere with [[steroid]] production. It is structurally and functionally similar to the other class I [[statin]]s [[mevastatin]], [[lovastatin]] and [[pravastatin]]. Both the drug and its <math>\beta</math>-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins. | ||
Revision as of 18:55, 20 May 2008
Simvastatin is a methylated derivative of lovastatin used treat hypercholesterolemia, to prevent heart attacks and strokes, and to diminish athlerosclorosis. It is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B. It inhibits the function of hydroxymethylglutaryl COA reductases, key enzymes in the production of cholesterol. It also increases LDL catabolism and may interfere with steroid production. It is structurally and functionally similar to the other class I statins mevastatin, lovastatin and pravastatin. Both the drug and its -hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins. is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B. Alcohol and grapefruit juice should be avoided when taking this medication.
Its IUPAC chemical name is [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl 1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate and its chemical formula is C25H38O5.
Brand names
- Cholestat
- Coledis
- Colemin
- Corolin
- Denan
- Labistatin
- Lipex
- Lodales
- Medipo
- Nivelipol
- Pantok
- Rendapid
- Simovil
- Simvastatin
- Simvastatina
- Simvastatine
- Simvastatinum
- Sinvacor
- Sivastin
- Synvinolin
- Vasotenal
- Vytorin
- Zocor
- Zocord
External links
- Simvastatin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Template:MedMaster
- Template:DrugBank