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'''Evidence-based medicine''' is defined as ''"the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients."'' [http://www.cebm.net/glossary.asp]. Better known as EBM, evidence based medicine began being discussed in 19XX, and now has . Why should such an approach to clinical medicine merit its own name, let alone another acronym in the medical literature? Don't physicians ordinarily conscientiously and judiciously use scientific evidence in treating patients? Isn't that simply routine medical care?  
'''Evidence-based medicine''' is defined as ''"the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients."'' [http://www.cebm.net/glossary.asp]. Better known as EBM, evidence based medicine began being discussed in 19XX, and now has . Why should such an approach to clinical medicine merit its own name, let alone another acronym in the medical literature? Don't physicians ordinarily conscientiously and judiciously use scientific evidence in treating patients? Isn't that simply routine medical care?  


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Evidence-based medicine is defined as "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients." [1]. Better known as EBM, evidence based medicine began being discussed in 19XX, and now has . Why should such an approach to clinical medicine merit its own name, let alone another acronym in the medical literature? Don't physicians ordinarily conscientiously and judiciously use scientific evidence in treating patients? Isn't that simply routine medical care?

In fact, most of the specific practices of physicians and surgeons are based on traditional techniques learned from their seniors in the care of patients during training, that are modified with personal clinical experience and information gleaned from the medical literature and continuing education courses. Although these practices almost always have a rational basis in biology, the actual efficacy of treatments is rarely explicitly proven by experimental trials in people. Further, even when the results of experimental trials or other evidence has first been reported, there is a lag time between accepting changes in procedures, treatments and tests in medical care at centers where such research is carried out or reviewed, and establishing them as routine practice generally in clinical care.

Evidence-based medicine seeks to promote practices that has been shown, through the scientific method to have validity by empiric proof. As such, it currently encompasses only a very small minority of actual practices in clinical medicine and surgery. More often, recommendations are made on the basis of best evidence that are reasonable, but not proven. Evidence-based medicine is also a philosophy, however, that seeks to validate practices by finding proof.

This article will discuss the field of evidence based medicine. In order to understand this approach to clinical care, some background in the history of medicine, experimental evidence in clinical medicine, and the ethics of medical experimentation must also be included.The philosophy of evidenced-based practice is not restricted to medicine among the health sciences, there are many nursing and other allied health science articles in the published peer-reviewed literature of these professions that use the term "evidence based medicine" as well.Evidence-Based Health Care extends the application of the principles of EBM to all professions associated with health care, including purchasing and management [2].

Experimental trials in clinical medicine:producing the evidence

Randomized controlled clinical trials

"A clinical trial is defined as a prospective scientific experiment that involves human subjects in whom treatment is initiated for the evaluation of a therapeutic intervention. In a randomized controlled clinical trial, each patient is assigned to receive a specific treatment intervention by a chance mechanism."(Stanley K. Design of randomized controlled trials. Circulation. 115(9):1164-9, 2007 Mar 6. UI: 17339574) The theory behind these trials is that the value of a treatment will be shown in an objective way, and, though usually unstated, there is an assumption that the results of the trial will be applicable to the care of patients who have the condition that was treated.


Ethics in randomization

Is it ethical to treat patients according to a randomization schedule? The answer is:sometimes, depending on the choice of treatments, the medical condition of the patient, and whether the patient has a choice in the matter. Take a university professor who has just received the devastating diagnosis of a malignant brain tumor. Let us say that this particular tumor is resistant to radiation treatment and has infiltrated too much of the brain to be surgically removed, the professor has a fatal disease. There is one drug (Drug A) that has shown a limited benefit in clinical practice to retarding the growth of this tumor, but there not only no known cure for the professor's condition, there is not even a truly effective treatment to slow the progression of the disease. There is a thoeretical reason to believe that Drug B may be curative-or at least helpful, and Drug B has been tested in animal studies that indicate it should be reasonably safe in humans. In this situation, asking the professor to participate in a trial of Drug A, versus Drug B, in which the choice will be according to a code generated by a computer program is not unethical, assuming that the professor understands and agrees. However, let's change the scenerio. If there is a treatment that has some benefit, is it ethical then to ask for the professor's participation in this study? Let's go further, perhaps there is a treatment that has been reported to cure 10% of patients?

In most randomized trials, there is

External validation

Major tools

Systematic review

Meta-analysis

Incorporating evidence into clinical care

Practicing clinicians usually cite the lack of time for reading newer textbooks or journals. However, the emergence of new types of evidence can change the way doctors treat patients. Unfortuantely the recent scientific evidence gathered through well controlled clinical trials usually do not reach the busy clinicians in real time. Another potential problem lies in the fact that there may be numerous trials on similar interventions and outcomes but they are not systematically reviewed or meta-analyzed.

Medical informatics

An essential adjunct to the practice of evidence-based medicine (EBM) is medical informatics (MI) which focuses on creating tools to access and apply the best evidence for making decisions about patient care [Sackett et al, 2000].

Before practicing EBM, informaticians (or informationists) must be familiar with medical journals, literature databases, medical textbooks, practice guidelines, and the growing number of other dedicated evidence-based resources, like the Cochrane Database of Systematic Reviews and Clinical Evidence [Mendelson and Carino 2005].

Similarly, for practicing medical informatics properly, it is essential to have an understanding of EBM, including the ability to phrase an answerable question, locate and retrieve the best evidence, and critically appraise and apply it [Hersh 2002, Shearer et al., 2001].

References

  1. Sackett DL, Straus SE, Richardson WS, Rosenberg W, Haynes RB. Evidence-based medicine: how to practice and teach EBM. 2nd ed. New York, NY: Churchhill Livingstone, 2000.
  2. Mendelson D, Carino TV, Evidence-Based Medicine In The United States-De Rigueur Or Dream Deferred? Health Affairs, 2005, 24: 133 - 136. doi: 10.1377/hlthaff.24.1.133
  3. Hersh W, Medical informatics education: an alternative pathway for training informationists, J Med Libr Assoc, 2002, 90(1): 76 - 79.
  4. Shearer BS, Seymour A, Capitani C. Bringing the best of medical librarianship to the patient team, J Med Libr Assoc 2001; 90: 22-31.

See also

External links

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