Hodgkin's disease: Difference between revisions
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Also called '''Hodgkin disease''' and '''Hodgkin's lymphoma''', '''Hodgkin's disease''' is a malignant, but potentially curable, disease of the lymph nodes, spleen, and general lymphoid tissue. | |||
Five variants are defined by the [[World Health Organization]], grouped into two classes:<ref>Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001.</ref> | |||
*Classical | |||
**nodular sclerosis | |||
**mixed cellularity | |||
**lymphocyte depleted | |||
**lymphocyte rich | |||
*nodular lymphocyte predominant Hodgkin disease (NLPHD). | |||
Classical and NLHPD are different clinical entities.<ref name=eMed>{{citation | |||
| title = Hodgkin Disease: Overview | |||
| author = Scott K Dessain, James L Spears, Athanassios Argiris | |||
| journal = eMedicine | |||
| date = 22 December 2009 | |||
| url = http://emedicine.medscape.com/article/201886-overview}}</ref> | |||
In the classical variant, giant usually multinucleate Hodgkin's and [[Reed-Sternberg cells]], the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. | |||
==References== | |||
{{reflist}} | |||
Revision as of 20:39, 1 July 2010
Also called Hodgkin disease and Hodgkin's lymphoma, Hodgkin's disease is a malignant, but potentially curable, disease of the lymph nodes, spleen, and general lymphoid tissue.
Five variants are defined by the World Health Organization, grouped into two classes:[1]
- Classical
- nodular sclerosis
- mixed cellularity
- lymphocyte depleted
- lymphocyte rich
- nodular lymphocyte predominant Hodgkin disease (NLPHD).
Classical and NLHPD are different clinical entities.[2]
In the classical variant, giant usually multinucleate Hodgkin's and Reed-Sternberg cells, the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
References
- ↑ Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001.
- ↑ Scott K Dessain, James L Spears, Athanassios Argiris (22 December 2009), "Hodgkin Disease: Overview", eMedicine