Colchicine: Difference between revisions
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===Prevention of gout=== | ===Prevention of gout=== | ||
[[Clinical practice guideline]]s recommend 0.5 to 1.0 mg per day.<ref name="pmid16707532">{{cite journal |author=Zhang W, Doherty M, Bardin T, ''et al'' |title=EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) |journal=Ann. Rheum. Dis. |volume=65 |issue=10 |pages=1312–24 |year=2006 |month=October |pmid=16707532 |doi=10.1136/ard.2006.055269 |url=http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=16707532 |issn=}}</ref> | [[Clinical practice guideline]]s recommend 0.5 to 1.0 mg per day.<ref name="pmid16707532">{{cite journal |author=Zhang W, Doherty M, Bardin T, ''et al'' |title=EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) |journal=Ann. Rheum. Dis. |volume=65 |issue=10 |pages=1312–24 |year=2006 |month=October |pmid=16707532 |doi=10.1136/ard.2006.055269 |url=http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=16707532 |issn=}}</ref> | ||
==Drug interactions== | |||
Colchicine is metabolized by the CYP3A4 [[isoenzyme]] of [[cytochrome P-450]]. | |||
==References== | ==References== | ||
Revision as of 20:24, 25 January 2009
In pharmacology, colchicine is a "major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (period disease)."[1]
Dosage
Acute gout attack
Initially 1 to 1.2 milligrams, then one of the following until symptoms better or gastrointestinal drug toxicity (stomach pain, vomiting or diarrhea) occur:[2]
- 0.5 to 0.6 milligram every hour
- 1 to 1.2 milligrams every two hours. 0.5 mg every 2 hours has been used, but still causes consistent toxicity[3]
- 0.5 to 0.6 milligram every 2 to 3 hours
The maximum dose per attack is 4 to 8 milligrams total.
Prevention of gout
Clinical practice guidelines recommend 0.5 to 1.0 mg per day.[4]
Drug interactions
Colchicine is metabolized by the CYP3A4 isoenzyme of cytochrome P-450.
References
- ↑ Anonymous (2024), Colchicine (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Colchicine. In: DRUGDEX® System (Internet database). Greenwood Village, Colo: Thomson Healthcare. Updated periodically.
- ↑ Ahern MJ, Reid C, Gordon TP, McCredie M, Brooks PM, Jones M (June 1987). "Does colchicine work? The results of the first controlled study in acute gout". Aust N Z J Med 17 (3): 301–4. DOI:10.1111/j.1445-5994.1987.tb01232.x. PMID 3314832. Research Blogging. Summary at Bandolier
- ↑ Zhang W, Doherty M, Bardin T, et al (October 2006). "EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)". Ann. Rheum. Dis. 65 (10): 1312–24. DOI:10.1136/ard.2006.055269. PMID 16707532. Research Blogging.
External references
The most up-to-date information about Colchicine and other drugs can be found at the following sites.
- Colchicine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Colchicine - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Colchicine - Detailed information from DrugBank.